ArticleJournal of virology2008
Primary human hepatocytes are susceptible to infection by hepatitis delta virus assembled with envelope proteins of woodchuck hepatitis virus.
Article in Journal of virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Host cell-dependent late entry step as determinant of hepatitis B virus infection.PLoS pathogens · 2022Article
- A nuanced role of the small loop of hepatitis B virus small envelope protein in virion morphogenesis and secretion.Journal of biomedical science · 2021Article
- Article
- Review
- HDV-Like Viruses.Viruses · 2021Review
- Identification of novel avian and mammalian deltaviruses provides new insights into deltavirus evolution.Virus evolution · 2021Article
- Art of Making Artificial Liver: Depicting Human Liver Biology and Diseases in Mice.Seminars in liver disease · 2020Review
- Analysis of Host Responses to Hepatitis B and Delta Viral Infections in a Micro-scalable Hepatic Co-culture System.Hepatology (Baltimore, Md.) · 2020Article
- Article
- The potential of cell sheet technique on the development of hepatocellular carcinoma in rat models.PloS one · 2017Article
- Support of the infectivity of hepatitis delta virus particles by the envelope proteins of different genotypes of hepatitis B virus.Journal of virology · 2014Article
- Envelope proteins derived from naturally integrated hepatitis B virus DNA support assembly and release of infectious hepatitis delta virus particles.Journal of virology · 2014Article
- Virus entry mediated by hepatitis B virus envelope proteins.World journal of gastroenterology · 2013Review
- Bats carry pathogenic hepadnaviruses antigenically related to hepatitis B virus and capable of infecting human hepatocytes.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Entry of hepatitis B virus into immortalized human primary hepatocytes by clathrin-dependent endocytosis.Journal of virology · 2012Article
- Fine mapping of pre-S sequence requirements for hepatitis B virus large envelope protein-mediated receptor interaction.Journal of virology · 2010Article
- The pre-S1 and antigenic loop infectivity determinants of the hepatitis B virus envelope proteins are functionally independent.Journal of virology · 2009Article
- A function essential to viral entry underlies the hepatitis B virus "a" determinant.Journal of virology · 2009Article
- HBV life cycle: entry and morphogenesis.Viruses · 2009Article
- Experimental mouse models for hepatocellular carcinoma research.International journal of experimental pathology · 2009Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Hepatitis B virus (HBV) and hepatitis delta virus (HDV) share the HBV envelope proteins. When woodchucks chronically infected with woodchuck hepatitis virus (WHV) are superinfected with HDV, they produce HDV with a WHV envelope, wHDV. Several lines of evidence are provided that wHDV infects not only cultured primary woodchuck hepatocytes (PWH) but also primary human hepatocytes (PHH). Surprisingly, HBV-enveloped HDV (hHDV) and wHDV infected PHH with comparable efficiencies; however, hHDV did not infect PWH. The basis for these host range specificities was investigated using as inhibitors peptides bearing species-specific pre-S (where S is the small envelope protein) sequences. It was found that pre-S1 contributed to the ability of wHDV to infect both PHH and PWH. In addition, the inability of hHDV to infect PWH was not overcome using a chimeric form of hHDV containing WHV S protein, again supporting the essential role of pre-S1 in infection of target cells. One interpretation of these data is that host range specificity of HDV is determined entirely by pre-S1 and that the WHV and HBV pre-S1 proteins recognize different receptors on PHH.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.