ArticleNucleic acids research2008
Discovery of novel tumor suppressor p53 response elements using information theory.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Whole-genome functional characterization of RE1 silencers using a modified massively parallel reporter assay.Cell genomics · 2023Article
- Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress.Cancer & metabolism · 2013Article
- DeGNServer: deciphering genome-scale gene networks through high performance reverse engineering analysis.BioMed research international · 2013Article
- The next generation of transcription factor binding site prediction.PLoS computational biology · 2013Article
- The role of D-GADD45 in oxidative, thermal and genotoxic stress resistance.Cell cycle (Georgetown, Tex.) · 2012Article
- Gene-specific transcription activation via long-range allosteric shape-shifting.The Biochemical journal · 2011Review
- The Regulation of Aging and Longevity: A New and Complex Role of p53.Genes & cancer · 2011Article
- Article
- p53 Protects lung cancer cells against metabolic stress.International journal of oncology · 2010Article
- 70% efficiency of bistate molecular machines explained by information theory, high dimensional geometry and evolutionary convergence.Nucleic acids research · 2010Article
- A brief review of molecular information theory.Nano communication networks · 2010Article
- Mechanisms of transcription factor selectivity.Trends in genetics : TIG · 2010Review
- Data Compression Concepts and Algorithms and their Applications to Bioinformatics.Entropy (Basel, Switzerland) · 2010Article
- p53 and metabolism.Nature reviews. Cancer · 2009Review
- Cooperativity dominates the genomic organization of p53-response elements: a mechanistic view.PLoS computational biology · 2009Article
- Homeostatic functions of the p53 tumor suppressor: regulation of energy metabolism and antioxidant defense.Seminars in cancer biology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
An accurate method for locating genes under tumor suppressor p53 control that is based on a well-established mathematical theory and built using naturally occurring, experimentally proven p53 sites is essential in understanding the complete p53 network. We used a molecular information theory approach to create a flexible model for p53 binding. By searching around transcription start sites in human chromosomes 1 and 2, we predicted 16 novel p53 binding sites and experimentally demonstrated that 15 of the 16 (94%) sites were bound by p53. Some were also bound by the related proteins p63 and p73. Thirteen of the adjacent genes were controlled by at least one of the proteins. Eleven of the 16 sites (69%) had not been identified previously. This molecular information theory approach can be extended to any genetic system to predict new sites for DNA-binding proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.