ReviewCarcinogenesis2008
Defining the blueprint of the cancer genome.
Review in Carcinogenesis, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Differential effects of NOD2 polymorphisms on colorectal cancer risk: a meta-analysis.International journal of colorectal disease · 2010Pooled it
- Tumor Take Rate Optimization for Colorectal Carcinoma Patient-Derived Xenograft Models.BioMed research international · 2016Article
- Establishment and characterization of cell lines from chromosomal instable colorectal cancer.World journal of gastroenterology · 2015Article
- Epithelial cancers in the post-genomic era: should we reconsider our lifestyle?Cancer metastasis reviews · 2013Review
- ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Article
- miR-23a promotes the transition from indolent to invasive colorectal cancer.Cancer discovery · 2012Article
- Efficient association analysis between colorectal cancer and allelic polymorphisms of HLA-DQB1 by comparison of age of onset.Oncology letters · 2012Article
- Mutual exclusivity analysis identifies oncogenic network modules.Genome research · 2012Article
- Oncogene addiction as a foundational rationale for targeted anti-cancer therapy: promises and perils.EMBO molecular medicine · 2011Review
- Article
- Identification of gene fusion transcripts by transcriptome sequencing in BRCA1-mutated breast cancers and cell lines.BMC medical genomics · 2011Article
- Endometrial cancer and genetic variation in PTEN, PIK3CA, AKT1, MLH1, and MSH2 within a population-based case-control study.Gynecologic oncology · 2011Article
- CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer.Oncogene · 2010Article
- PROBING CANCER SIGNALING WITH RESONANT WAVEGUIDE GRATING BIOSENSORS.Expert opinion on drug discovery · 2010Article
- Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy.Nature genetics · 2010Article
- Article
- Cancer gene discovery in hepatocellular carcinoma.Journal of hepatology · 2010Review
- Article
- PKC and the control of localized signal dynamics.Nature reviews. Molecular cell biology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
It is widely accepted that cancer is a disease caused by accumulation of mutations in specific genes. These tumor-specific mutations provide clues to the cellular processes underlying tumorigenesis and have proven useful for diagnostic and therapeutic purposes. To date, however, only a small fraction of genes has been analyzed and the number and type of alterations responsible for the development of common tumor types are unknown. The determination of the human genome sequence coupled with improvements in sequencing and bioinformatic approaches have made it possible to examine the cancer cell genome in a comprehensive and unbiased manner. Systematic sequencing studies have been performed on gene families involved in signal transduction in several tumor types, and have now been extended to include the majority of protein-coding genes in breast and colorectal cancers. These analyses have identified new genes and pathways that had not been linked previously to human cancer. One example has been the discovery of genetic alterations in the PIK3CA gene encoding p110alpha phosphatidylinositol 3-kinase and in related pathway genes in >30% of colon and breast cancers. These mutational analyses provide a window into the genetic landscape of human cancer, indicate new targets for personalized diagnostic and therapeutic intervention, and suggest lessons for future large-scale genomic analyses in human tumors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.