ArticleExperimental hematology2008
AMD3100 synergizes with G-CSF to mobilize repopulating stem cells in Fanconi anemia knockout mice.
Article in Experimental hematology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Gata2 noncoding genetic variation as a determinant of hematopoietic stem/progenitor cell mobilization efficiency.Blood advances · 2023Article
- Article
- Glucose oxidase induces mobilization of long-term repopulating hematopoietic cells in mice.Stem cells translational medicine · 2021Article
- Improved collection of hematopoietic stem cells and progenitors from Fanconi anemia patients for gene therapy purposes.Molecular therapy. Methods & clinical development · 2021Article
- Numbers of long-term hematopoietic stem cells from bone marrow of fanca and fancc knockout mice can be greatly enhanced by their collection and processing in physioxia conditions.Blood cells, molecules & diseases · 2021Article
- Fancd2-deficient hematopoietic stem and progenitor cells depend on augmented mitochondrial translation for survival and proliferation.Stem cell research · 2019Article
- Quickly attainable and highly engrafting hematopoietic stem cells.Blood science (Baltimore, Md.) · 2019Article
- Targeting the molecular and cellular interactions of the bone marrow niche in immunologic disease.Current allergy and asthma reports · 2014Review
- Interleukin 8/KC enhances G-CSF induced hematopoietic stem/progenitor cell mobilization in Fancg deficient mice.Stem cell investigation · 2014Article
- Alpha-tocopherol succinate- and AMD3100-mobilized progenitors mitigate radiation combined injury in mice.Journal of radiation research · 2014Article
- Article
- Inflammation-mediated notch signaling skews fanconi anemia hematopoietic stem cell differentiation.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- The nucleotide sugar UDP-glucose mobilizes long-term repopulating primitive hematopoietic cells.The Journal of clinical investigation · 2013Article
- Gene therapy for Fanconi anemia: one step closer to the clinic.Human gene therapy · 2012Article
- Article
- Stem cell gene therapy for fanconi anemia: report from the 1st international Fanconi anemia gene therapy working group meeting.Molecular therapy : the journal of the American Society of Gene Therapy · 2011Review
- Finding the needle in the hay stack: hematopoietic stem cells in Fanconi anemia.Mutation research · 2009Review
- Article
- Insights into the biology of mobilized hematopoietic stem/progenitor cells through innovative treatment schedules of the CXCR4 antagonist AMD3100.Experimental hematology · 2009Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Fanconi anemia (FA) is a heterogeneous inherited disorder characterized by a progressive bone marrow (BM) failure and susceptibility to myeloid leukemia. Genetic correction using gene-transfer technology is one potential therapy. A major hurdle in applying this technology in FA patients is the inability of granulocyte colony-stimulating factor (G-CSF) to mobilize sufficient numbers of hematopoietic stem (HSC)/progenitor cells (HPC) from the BM to the peripheral blood. Whether the low number of CD34(+) cells is a result of BM hypoplasia or an inability of G-CSF to adequately mobilize FA HSC/HPC remains incompletely understood. Here we use competitive repopulation of lethally irradiated primary and secondary recipients to show that in two murine models of FA, AMD3100 synergizes with G-CSF resulting in a mobilization of HSC, whereas G-CSF alone fails to mobilize stem cells even in the absence of hypoplasia.
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