Evidence map›Paper›PMID 18495291›Full record

ReviewAdvanced drug delivery reviews2008

Bioconjugated quantum dots for in vivo molecular and cellular imaging.

Andrew M Smith, Hongwei Duan, Aaron M Mohs, Shuming Nie

Abstract readReview
In one paragraph

Review in Advanced drug delivery reviews, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 243 papers.

0numbers the graph read from it
0cells of the map it votes in
243citing papers in PubMed
38.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

243 citing papers in PubMed, 1,165 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review

183 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Andrew M SmithDepartments of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, 101 Woodruff Circle, Suite 2001, Atlanta, GA 30322, USA.
Hongwei Duan
Aaron M Mohs
Shuming Nie
Emory University · USGeorgia Institute of Technology · US

Funding

Nanomedicine Center for Nucleoprotein MachinesPN2EY018244 · NEI · RICE UNIVERSITY · PI BAO, GANG · 2006 to 2015
$24.4M
Tissue and Animal UseU54CA119338 · NCI · EMORY UNIVERSITY · PI SHIN, DONG M · 2005 to 2009
$18.4M
Nanotechnology: Detection &Analysis of Plaque FormationU01HL080711 · NHLBI · EMORY UNIVERSITY · PI BAO, GANG · 2005 to 2009
$11.0M
Nanotechnology Linking Biomarkers with Cancer BehaviorR01CA108468 · NCI · EMORY UNIVERSITY · PI NIE, SHUMING · 2004 to 2008
$6.9M
Bioaffinity Nanoparticle Probes for Bioimaging (RMI)P20GM072069 · NIGMS · EMORY UNIVERSITY · PI NIE, SHUMING · 2004 to 2007
$2.6M
NCI NIH HHS R01 CA108468NCI NIH HHS U54 CA119338NCI NIH HHS U54CA119338NEI NIH HHS PN2 EY018244NHLBI NIH HHS U01 HL080711NHLBI NIH HHS U01HL080711NIGMS NIH HHS P20 GM072069
6 · The paper itself

Abstract

Semiconductor quantum dots (QDs) are tiny light-emitting particles on the nanometer scale, and are emerging as a new class of fluorescent labels for biology and medicine. In comparison with organic dyes and fluorescent proteins, they have unique optical and electronic properties, with size-tunable light emission, superior signal brightness, resistance to photobleaching, and broad absorption spectra for simultaneous excitation of multiple fluorescence colors. QDs also provide a versatile nanoscale scaffold for designing multifunctional nanoparticles with both imaging and therapeutic functions. When linked with targeting ligands such as antibodies, peptides or small molecules, QDs can be used to target tumor biomarkers as well as tumor vasculatures with high affinity and specificity. Here we discuss the synthesis and development of state-of-the-art QD probes and their use for molecular and cellular imaging. We also examine key issues for in vivo imaging and therapy, such as nanoparticle biodistribution, pharmacokinetics, and toxicology.

Indexed as

Quantum DotsAnimalsBiocompatible MaterialsDiagnostic ImagingDrug Delivery SystemsHumansNanotechnologyNeoplasmsTissue DistributionBiocompatible Materials

Identifiers

PMID18495291
PMCPMC2649798
OpenAlexW2052745039

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.