ArticleChemosphere2008
DDT and its metabolites in breast milk from the Madeira River basin in the Amazon, Brazil.
Article in Chemosphere, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pesticide contamination of lactating mothers' milk in Latin America: a systematic review.Revista de saude publica · 2024Pooled it
- Global Evidence on Monitoring Human Pesticide Exposure.Journal of xenobiotics · 2025Review
- Persistent Organic Pollutant Levels in Maternal and Cord Blood Plasma and Breast Milk: Results from the Rio Birth Cohort Pilot Study of Environmental Exposure and Childhood Development (PIPA Study).International journal of environmental research and public health · 2022Article
- Endocrine-Disrupting Organochlorine Pesticides in Human Breast Milk: Changes during Lactation.Nutrients · 2021Article
- Exposure to Endocrine Disrupting Chemicals and Risk of Breast Cancer.International journal of molecular sciences · 2020Review
- Excretion kinetics of three dominant organochlorine compounds in human milk within the first 6 months postpartum.Environmental monitoring and assessment · 2018Article
- Inhibitor of Differentiation-3 and Estrogenic Endocrine Disruptors: Implications for Susceptibility to Obesity and Metabolic Disorders.BioMed research international · 2018Review
- Modeling the dynamics of DDT in a remote tropical floodplain: indications of post-ban use?Environmental science and pollution research international · 2016Article
- Spatial and temporal trends of the Stockholm Convention POPs in mothers' milk -- a global review.Environmental science and pollution research international · 2015Article
- Organochlorine pesticides residue in breast milk: a systematic review.Medical journal of the Islamic Republic of Iran · 2015Review
- Bulk atmospheric deposition of persistent toxic substances (PTS) along environmental gradients in Brazil.Environmental science and pollution research international · 2013Article
- Development and application of an indirect competitive enzyme-linked immunosorbent assay for the detection of p,p'-DDE in human milk and comparison of the results against GC-ECD.Journal of agricultural and food chemistry · 2012Article
- Article
- Exposure to toxic chemicals in the diet: is the Brazilian population at risk?Journal of exposure science & environmental epidemiologyReview
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Until the 1990s the 1,1,1-trichloro-bis-2,2'-(4chlorophenyl) ethane (DDT) was sprayed in the walls of the house along the Madeira River basin, Brazilian Amazon, a region well known for its large number of malaria cases. In 1910, Oswaldo Cruz described the presence of malaria in 100% of the population living in some localities from the Madeira River basin. Data available in the literature point to the DDT contamination in fishes captured in Madeira River region. Fish is the major source of dietary protein to these people. DDT tends to accumulate in lipid rich tissues and is being eliminated by different events, including lactation. Considering the importance of feeding breast milk to the children, the associated risks of DDT exposure via breast milk intake to children must be assessed. This is the main objective of this work: to analyse the presence of the p,p'-DDT and its metabolites p,p'-DDE and p,p'-DDD in 69 human milk samples and to estimate the intake of DDT and its metabolite in terms of total DDT (total DDT=p,p'-DDE+p,p'-DDD+p,p'-DDT). All the samples showed contamination with DDT and its metabolites ranging from 25.4 to 9361.9 ng of total DDT/g of lipid (median=369.6 ng of total DDT/g of lipid) and 8.7% of the estimated daily intake (EDI), in terms of total DDT, which was higher than the acceptable daily intake proposed by the WHO.
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Registered trials
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