ArticleJournal of cellular and molecular medicine2008
Thrombin bound to a fibrin clot confers angiogenic and haemostatic properties on endothelial progenitor cells.
Article in Journal of cellular and molecular medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 54 citations in OpenAlex.
- Progressive endothelial coverage enhances hemocompatibility and prevents calcification in bioprosthetic valve tissue.Angiogenesis · 2026Article
- Human endothelial colony forming cells (ECFCs) require endothelial protein C receptor (EPCR) for cell cycle progression and angiogenic activity.Angiogenesis · 2025Article
- iPSC-Derived Hereditary Breast Cancer Model Reveals theInternational journal of molecular sciences · 2021Article
- Valproic Acid Decreases Endothelial Colony Forming Cells Differentiation and Induces Endothelial-to-Mesenchymal Transition-like Process.Stem cell reviews and reports · 2020Article
- The Relationship Between Nailfold Microcirculation and Retinal Microcirculation in Healthy Subjects.Frontiers in physiology · 2020Article
- Egfl7 Represses the Vasculogenic Potential of Human Endothelial Progenitor Cells.Stem cell reviews and reports · 2018Article
- Coagulation and the vessel wall in pulmonary embolism.Pulmonary circulation · 2013Review
- Fibrin acts as biomimetic niche inducing both differentiation and stem cell marker expression of early human endothelial progenitor cells.Cell proliferation · 2011Article
- Improved survival, vascular differentiation and wound healing potential of stem cells co-cultured with endothelial cells.PloS one · 2011Article
- Thrombin and exercise similarly influence expression of cell cycle genes in cultured putative endothelial progenitor cells.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Article
- Interleukin 8 is differently expressed and modulated by PAR-1 activation in early and late endothelial progenitor cells.Journal of cellular and molecular medicine · 2009Article
- CD34+ cells augment endothelial cell differentiation of CD14+ endothelial progenitor cells in vitro.Journal of cellular and molecular medicine · 2009Article
- High-density lipoprotein exerts vasculoprotection via endothelial progenitor cells.Journal of cellular and molecular medicineArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent data suggest that endothelial progenitor cells (EPCs) are involved in recanalizing venous thrombi. We examined the impact of a fibrin network, and particularly of adsorbed thrombin, on EPCs derived from cord blood CD34(+) cells. Fibrin networks generated in microplates by adding CaCl(2) to platelet-depleted plasma retained adsorbed thrombin at the average concentration of 4.2 nM per well. EPCs expressed high levels of endothelial cell protein C receptor and thrombomodulin, allowing the generation of activated protein C on the fibrin matrix in the presence of exogenous human protein C. The fibrin matrix induced significant EPC proliferation and, when placed in the lower chamber of a Boyden device, strongly enhanced EPC migration. These effects were partly inhibited by hirudin by 41% and 66%, respectively), which suggests that fibrin-adsorbed thrombin interacts with EPCs via the thrombin receptor PAR-1. Finally, spontaneous lysis of the fibrin network, studied by measuring D-dimer release into the supernatant, was inhibited by EPCs but not by control mononuclear cells. Such an effect was associated with a 10-fold increase in plasminogen activator inhibitor-1 (PAI-1) secretion by EPCs cultivated in fibrin matrix. Overall, our data show that EPCs, in addition to their angiogenic potential, have both anticoagulant and antifibrinolytic properties. Thrombin may modulate these properties and contribute to thrombus recanalization by EPCs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.