Trial reportInternational wound journal2008
A randomised controlled 8-week crossover clinical evaluation of the 3M Coban 2 Layer Compression System versus Profore to evaluate the product performance in patients with venous leg ulcers.
Trial report in International wound journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 5 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Effect of Unna's boot on venous ulcer healing: a systematic review and meta-analysis.Revista da Escola de Enfermagem da U S P · 2024Pooled it
- A meta-review of the impact of compression therapy on venous leg ulcer healing.International wound journal · 2023Pooled it
- Compression bandages or stockings versus no compression for treating venous leg ulcers.The Cochrane database of systematic reviews · 2021Pooled it
- Compression for venous leg ulcers.The Cochrane database of systematic reviews · 2012Pooled it
- Venous leg ulcers.BMJ clinical evidence · 2011Pooled it
- Compression therapies for venous leg ulcers: The VENous Ulcer Study 6 (VenUS 6), an open, multicentre, randomised clinical trial.PLoS medicine · 2026Trial
- [Effectiveness of double-layered compression therapy against crepe bandage for healing venous ulcers in primary care. Randomized clinical trial].Atencion primaria · 2020Trial
- Adaptive compression therapy for venous leg ulcers: a clinically effective, patient-centred approach.International wound journal · 2016Trial
- The impact of providing product funding for compression bandaging and medical footwear on compression use, wound healing and quality of life.International wound journal · 2012Trial
- Compression systems for venous leg ulcers: a network meta-analysis and cost-effectiveness analysis.EClinicalMedicine · 2026Article
- Article
- [Venous ulcus cruris-Surgical treatment].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2022Article
- Cost of managing patients with venous leg ulcers.International wound journal · 2020Article
- The financial and quality-of-life cost to patients living with a chronic wound in the community.International wound journal · 2017Article
- ECAMulticapa: Effectiveness of double-layered compression therapy for healing venous ulcers in primary care: a Study Protocol.BMC nursing · 2016Article
- Network meta-analysis of (individual patient) time to event data alongside (aggregate) count data.BMC medical research methodology · 2014Article
- What Do Patients Want? Patient Preference in Wound Care.Advances in wound care · 2014Article
- 3M Coban 2 Layer Compression Therapy: Intelligent Compression Dynamics to Suit Different Patient Needs.Advances in wound care · 2012Article
- [Therapy of venous leg ulcers. New and established approaches].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2011Review
- Impact of lower extremity venous ulcers due to chronic venous insufficiency on quality of life.The open cardiovascular medicine journal · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 9 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study compared a two-layer (Coban 2 Layer) and a four-layer (Profore) compression bandage system in venous leg ulcer patients. Participants (n = 81) were enrolled into an 8-week, randomised, open-label, ten-centre, crossover clinical trial. The primary endpoint was bandage slippage measured at each dressing change. Secondary endpoints included wound healing, health-related quality of life (HRQoL) and patient preference. Mean slippage estimated from a mixed analysis of variance model (697 visits) was 2.48 cm for the two-layer system and 4.17 cm for the four-layer system (P < 0.001). There were no significant differences in percent of wounds that healed (Fisher's exact test, P = 0.30), in wound area reduction (Wilcoxon rank-sum test, P = 0.88) or in linear healing rate (Wilcoxon rank-sum test, P = 0.94). The HRQoL Physical Symptoms and Daily Living scores were significantly higher with the two-layer system (pooled two-sample t-test, P < 0.05). Patients had a strong preference for the two-layer system (72%) than the four-layer system (22%), with 6% having no preference. In conclusion, the two-layer system exhibited significantly less bandage slippage than the four-layer system. While less bandage slippage did not appear to impact wound healing, there was indication that it may have influenced patient preference in favour of the two-layer system and potentially impacted patients' HRQoL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.