ArticleMolecular and cellular biochemistry2008
Expression patterns of AMP-deaminase isozymes in human hepatocellular carcinoma (HCC).
Article in Molecular and cellular biochemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 8 papers, 1 of them a synthesis that pooled it.
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8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Cross-ancestry GWAS meta-analysis identifies six breast cancer loci in African and European ancestry women.Nature communications · 2021Pooled it
- Identification of four novel hub genes as monitoring biomarkers for colorectal cancer.Hereditas · 2022Article
- Comprehensive Analysis of Prognostic Value and Immune Infiltration of the NT5DC Family in Hepatocellular Carcinoma.Journal of oncology · 2022Article
- Overexpression of AMPD2 indicates poor prognosis in colorectal cancer patientsWorld journal of clinical cases · 2020Review
- A mutation in Ampd2 is associated with nephrotic syndrome and hypercholesterolemia in mice.Lipids in health and disease · 2014Article
- Obesity increases tumor aggressiveness in a genetically engineered mouse model of serous ovarian cancer.Gynecologic oncology · 2014Article
- Participation of the oviductal s100 calcium binding protein G in the genomic effect of estradiol that accelerates oviductal embryo transport in mated rats.Reproductive biology and endocrinology : RB&E · 2011Article
- Iron-dependent regulation of MDM2 influences p53 activity and hepatic carcinogenesis.The American journal of pathology · 2010Article
Corrections and comments
- Retracted
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAMP-deaminase (EC 3.5.4.6) is an enzyme of nucleotide breakdown involved in regulation of energetic metabolism in mammalian cells. The enzyme is coded by a family of three independent genes (AMPD1, AMPD2 and AMPD3), synthesizing three different isozymes. In mammalian liver, the reaction catalyzed by AMP-deaminase constitutes a rate-limiting step in adenine nucleotide catabolism. In neoplastic liver, adenine nucleotide catabolism is a subject of many modifications, which influence the expression of genes synthesizing enzymes regulating this pathway.
aimsThe experimental studies presented here illustrate the expression of AMPD genes in human liver neoplasm tumor (HCC, hepatocellular carcinoma).
methodsRT-PCR and Western blotting methods were used for determining of the goal mentioned above. RESULTS AND
conclusionExpression level of AMPD gene family in the tumorous fragment (HCC tumor) of neoplastic liver did not differ substantially from that found in the nontumorous (cirrhotic) fragment of the organ. In this case the expression of AMPD2 gene was prevailing. AMPD2 was the main isoform of AMP-deaminase identified in two liver fragments compared. This is a first report evidencing the pattern of AMPD genes expression in neoplastic human liver.
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