ArticleJournal of natural medicines2008
Antidiarrhoeal activity of the standardised extract of Cinnamomum tamala in experimental rats.
Article in Journal of natural medicines, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 67 citations in OpenAlex.
- Evaluation of radical scavenging and antibacterial potency of leaf extracts from indigenous species of Cinnamomum tamala and Ocimum sanctum.Biotechnology letters · 2026Article
- Renzhu Ointment Regulates L-Type Voltage-Dependent Calcium Channel in Mice Model of Senna-Induced Diarrhea by Transdermal Administration.Drug design, development and therapy · 2023Article
- Antidiarheal activity of catechol and ethyl 5, 8,11,14,17 - icosapentanoate-rich fraction ofJournal of traditional and complementary medicine · 2022Article
- Campomanesia adamantium Peel Extract in Antidiarrheal Activity: The Ability of Inhibition of Heat-Stable Enterotoxin by Polyphenols.PloS one · 2016Article
- The Pharmacological Effects of Benachio-F(®) on Rat Gastrointestinal Functions.Biomolecules & therapeutics · 2015Article
- GC-MS analysis and screening of antidiabetic, antioxidant and hypolipidemic potential of Cinnamomum tamala oil in streptozotocin induced diabetes mellitus in rats.Cardiovascular diabetology · 2012Article
- Direct analysis in real time by mass spectrometric technique for determining the variation in metabolite profiles of Cinnamomum tamala Nees and Eberm genotypes.TheScientificWorldJournal · 2012Article
- Antidiarrheal activity of Capparis zeylanica leaf extracts.Journal of advanced pharmaceutical technology & research · 2011Article
- Effect of hexane fraction of leaves of Cinnamomum tamala Linn on macrophage functions.Inflammopharmacology · 2010Article
- Therapeutic significance and pharmacological activities of antidiarrheal medicinal plants mention in Ayurveda: A review.Journal of intercultural ethnopharmacologyReview
- Antisecretory and antimotility activity of Aconitum heterophyllum and its significance in treatment of diarrhea.Indian journal of pharmacologyArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study was designed to investigate the antidiarrhoeal potential of 50% ethanolic extract of Cinnamomum tamala on experimentally induced castor oil diarrhoea, gastric emptying of phenol red meal, gastrointestinal transit of charcoal meal and in vitro mast cell degranulation activity. C. tamala extract (25, 50 and 100 mg/kg, orally) produced a dose-dependent reduction in the total amount of faecal matter in castor oil-induced diarrhoea. The mean distance travelled by charcoal meal at 50 and 100 mg/kg of extract showed a significant reduction in the secretion of gastrointestinal fluid accumulation by 32.5-65.0%. The Na(+) and K(+) concentrations on castor oil-induced fluid accumulation showed a greater inhibitory effect on Na(+) levels than on K(+) concentrations. C. tamala significantly reduced the lipid peroxidation (P < 0.001) and increased the catalase (P < 0.01) activity in comparison to the castor oil-induced groups. C. tamala leaf extract did not show any significant effect at a higher dose (15 mg/ml) on mast cell degranulation. However, the extract in the dose of 5 and 10 mg/ml conferred significant mast cell protective action (P < 0.001). The percentage of eugenol in extract is 3.8% w/w, and total tannin is 247.5 mg/g. The result indicates the Indian spice C. tamala is useful for diarrhoea.
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