ArticlePloS one2008
C2 and CFB genes in age-related maculopathy and joint action with CFH and LOC387715 genes.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetics of Age Related Maculopathy
A Multicenter Study on the Investigation of Previously Verified Leading Gene Polymorphisms Related to Age-related Macular Degeneration in Turkish Population
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.
- The association between complement component 2/complement factor B polymorphisms and age-related macular degeneration: a HuGE review and meta-analysis.American journal of epidemiology · 2012Pooled it
- Associations of Host Genetics and Plasma Proteomics with Incident Age-Related Macular Degeneration in Persons with AIDS.Ophthalmology science · 2026Article
- Clinical exome analysis and targeted gene repair of the c.1354dupT variant in iPSC lines from patients with PROM1-related retinopathies exhibiting diverse phenotypes.Stem cell research & therapy · 2024Article
- Publication Trends of Research on Polypoidal Choroidal Vasculopathy During 2001-2020: A 20-Year Bibliometric Study.Frontiers in medicine · 2021Article
- Single-Nucleotide Polymorphisms in Genes Predisposing to Leprosy in Leprosy Household Contacts in Zhejiang Province, China.Pharmacogenomics and personalized medicine · 2020Article
- Acadesine suppresses TNF-α induced complement component 3 (C3), in retinal pigment epithelial (RPE) cells.PloS one · 2020Article
- The effect of complement factor B gene variation on age-related macular degeneration in Iranian patients.Journal of current ophthalmology · 2019Article
- C-Reactive Protein as a Therapeutic Target in Age-Related Macular Degeneration.Frontiers in immunology · 2018Review
- Systematic Functional Testing of Rare Variants: Contributions of CFI to Age-Related Macular Degeneration.Investigative ophthalmology & visual science · 2017Article
- Advances in Age-related Macular Degeneration Understanding and Therapy.US ophthalmic review · 2017Article
- Risk factors and biomarkers of age-related macular degeneration.Progress in retinal and eye research · 2016Review
- AMD and the alternative complement pathway: genetics and functional implications.Human genomics · 2016Review
- Complement pathway biomarkers and age-related macular degeneration.Eye (London, England) · 2016Review
- Association between vitamin D status and age-related macular degeneration by genetic risk.JAMA ophthalmology · 2015Article
- Cellular models and therapies for age-related macular degeneration.Disease models & mechanisms · 2015Review
- Synthesis and propagation of complement C3 by microglia/monocytes in the aging retina.PloS one · 2014Article
- Complement system in pathogenesis of AMD: dual player in degeneration and protection of retinal tissue.Journal of immunology research · 2014Review
- Prediction of age-related macular degeneration in the general population: the Three Continent AMD Consortium.Ophthalmology · 2013Article
- The role of macrophage class a scavenger receptors in a laser-induced murine choroidal neovascularization model.Investigative ophthalmology & visual science · 2013Article
- Stem cells: a new paradigm for disease modeling and developing therapies for age-related macular degeneration.Journal of translational medicine · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAge-related maculopathy (ARM) is a common cause of visual impairment in the elderly populations of industrialized countries and significantly affects the quality of life of those suffering from the disease. Variants within two genes, the complement factor H (CFH) and the poorly characterized LOC387715 (ARMS2), are widely recognized as ARM risk factors. CFH is important in regulation of the alternative complement pathway suggesting this pathway is involved in ARM pathogenesis. Two other complement pathway genes, the closely linked complement component receptor (C2) and complement factor B (CFB), were recently shown to harbor variants associated with ARM. METHODS/PRINCIPAL
findingsWe investigated two SNPs in C2 and two in CFB in independent case-control and family cohorts of white subjects and found rs547154, an intronic SNP in C2, to be significantly associated with ARM in both our case-control (P-value 0.00007) and family data (P-value 0.00001). Logistic regression analysis suggested that accounting for the effect at this locus significantly (P-value 0.002) improves the fit of a genetic risk model of CFH and LOC387715 effects only. Modeling with the generalized multifactor dimensionality reduction method showed that adding C2 to the two-factor model of CFH and LOC387715 increases the sensitivity (from 63% to 73%). However, the balanced accuracy increases only from 71% to 72%, and the specificity decreases from 80% to 72%. CONCLUSIONS/SIGNIFICANCE: C2/CFB significantly influences AMD susceptibility and although accounting for effects at this locus does not dramatically increase the overall accuracy of the genetic risk model, the improvement over the CFH-LOC387715 model is statistically significant.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.