ArticleGenetics2008
Statistical power analysis of neutrality tests under demographic expansions, contractions and bottlenecks with recombination.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
118 citing papers in PubMed.
- Evolutionary history of the endangered Sanje mangabey (Cercocebus sanjei) in the Udzungwa Mountains, Tanzania: inferences from phylogeography and historical niche modelling.Primates; journal of primatology · 2026Article
- Population Structure and Local Adaptation ofAnimals : an open access journal from MDPI · 2026Article
- Multi-Marker Mitochondrial Analysis Reveals Genetic Diversity and Phylogenetic Relationships of Black Sea Sturgeons (Acipenseridae).Ecology and evolution · 2026Article
- Article
- Adaptive value of marginal populations: integrating selective signals, neutral processes and temporal scales.Heredity · 2026Article
- Phylogeography and Climate-Driven Distribution of Culex tarsalis (Diptera: Culicidae): Implications for the Global Spread of West Nile Virus.Acta parasitologica · 2026Article
- Retention ofPlants (Basel, Switzerland) · 2026Article
- Article
- Conservation genetic evaluation of Juniperus communis sensu lato in Slovakia.Scientific reports · 2025Article
- Phylogeographic and genetic insights into Sinonychia martensi: an endemic cave-dwelling harvestman in Beijing.BMC ecology and evolution · 2025Article
- Article
- Phlebotomine sand fly survey, blood meal source identification, and description of Sergentomyia imihra n. sp. in the central Sahara of Algeria.Parasites & vectors · 2024Article
- The Phylogeography and Diversification of an Endemic Trapdoor Spider Genus,Ecology and evolution · 2024Article
- Does the Colonizing Population Exhibit a Reduced Genetic Diversity and Allele Surfing? A Case Study of the Midday Gerbil (Animals : an open access journal from MDPI · 2024Article
- Characterizing the Phan Rang Sheep: A First Look at the Y Chromosome, Mitochondrial DNA, and Morphometrics.Animals : an open access journal from MDPI · 2024Article
- Whole-mitogenome analysis unveils previously undescribed genetic diversity in cane toads across their invasion trajectory.Ecology and evolution · 2024Article
- A renewed glance at the Palearctic golden eagle: Genetic variation in space and time.Ecology and evolution · 2024Article
- Assessing Phylogeographic Patterns and Genetic Diversity inZoological studies · 2024Article
- Genetic signatures of lineage fusion closely resemble population decline.Ecology and evolution · 2023Article
- Power of neutrality tests for detecting natural selection.G3 (Bethesda, Md.) · 2023Article
58 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several tests have been proposed to detect departures of nucleotide variability patterns from neutral expectations. However, very different kinds of evolutionary processes, such as selective events or demographic changes, can produce similar deviations from these tests, thus making interpretation difficult when a significant departure of neutrality is detected. Here we study the effects of demography and recombination upon neutrality tests by analyzing their power under sudden population expansions, sudden contractions, and bottlenecks. We evaluate tests based on the frequency spectrum of mutations and the distribution of haplotypes and explore the consequences of using incorrect estimates of the rates of recombination when testing for neutrality. We show that tests that rely on haplotype frequencies-especially Fs and ZnS, which are based, respectively, on the number of different haplotypes and on the r2 values between all pairs of polymorphic sites-are the most powerful for detecting expansions on nonrecombining genomic regions. Nevertheless, they are strongly affected by misestimations of recombination, so they should not be used when recombination levels are unknown. Instead, class I tests, particularly Tajima's D or R2, are recommended.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.