ArticleGenetics2008
Linkage disequilibrium under genetic hitchhiking in finite populations.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Genetic diversity and population structure analysis of Philippine native pigs highlight five priority populations for conservation.Ecology and evolution · 2023Article
- Review
- Linkage disequilibrium between rare mutations.Genetics · 2022Article
- Article
- Genomic Signatures of Reinforcement.Genes · 2018Review
- Rice diversity panel provides accurate genomic predictions for complex traits in the progenies of biparental crosses involving members of the panel.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2018Article
- A survey of methods and tools to detect recent and strong positive selection.Journal of biological research (Thessalonike, Greece) · 2017Review
- Refining the Use of Linkage Disequilibrium as a Robust Signature of Selective Sweeps.Genetics · 2016Article
- Scalable linkage-disequilibrium-based selective sweep detection: a performance guide.GigaScience · 2016Article
- Unraveling the genetic architecture of subtropical maize (Zea mays L.) lines to assess their utility in breeding programs.BMC genomics · 2013Article
- The effect of recurrent mutation on the linkage disequilibrium under a selective sweep.Journal of mathematical biology · 2012Article
- Article
- USING POPULATION GENOMICS TO DETECT SELECTION IN NATURAL POPULATIONS: KEY CONCEPTS AND METHODOLOGICAL CONSIDERATIONS.International journal of plant sciences · 2010Article
- Searching for footprints of positive selection in whole-genome SNP data from nonequilibrium populations.Genetics · 2010Article
- Article
- Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The model of genetic hitchhiking predicts a reduction in sequence diversity at a neutral locus closely linked to a beneficial allele. In addition, it has been shown that the same process results in a specific pattern of correlations (linkage disequilibrium) between neutral polymorphisms along the chromosome at the time of fixation of the beneficial allele. During the hitchhiking event, linkage disequilibrium on either side of the beneficial allele is built up whereas it is destroyed across the selected site. We derive explicit formulas for the expectation of the covariance measure D and standardized linkage disequilibrium sigma 2D between a pair of polymorphic sites. For our analysis we use the approximation of a star-like genealogy at the selected site. The resulting expressions are approximately correct in the limit of large selection coefficients. Using simulations we show that the resulting pattern of linkage disequilibrium is quickly-i.e., in <0.1N generations-destroyed after the fixation of the beneficial allele for moderately distant neutral loci, where N is the diploid population size.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.