ArticleGenetics2008
Analysis of the Drosophila melanogaster testes transcriptome reveals coordinate regulation of paralogous genes.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Genetic engineering for SIT application: a fruit fly-focused review.Insect science · 2026Review
- Metabolic regulation of proteome stability via N-terminal acetylation controls male germline stem cell differentiation and reproduction.Nature communications · 2023Article
- Population biology of accessory gland-expressed de novo genes in Drosophila melanogaster.Genetics · 2022Article
- Review
- Article
- A Continuum of Evolving De Novo Genes Drives Protein-Coding Novelty in Drosophila.Journal of molecular evolution · 2020Article
- Article
- Control of human testis-specific gene expression.PloS one · 2019Article
- Analysis of Drosophila melanogaster testis transcriptome.BMC genomics · 2018Article
- Article
- An analysis of 67 RNA-seq datasets from various tissues at different stages of a model insect, Manduca sexta.BMC genomics · 2017Article
- Repeated Duplication of Argonaute2 Is Associated with Strong Selection and Testis Specialization in Drosophila.Genetics · 2016Article
- Spermatogenesis Drives Rapid Gene Creation and Masculinization of the X Chromosome in Stalk-Eyed Flies (Diopsidae).Genome biology and evolution · 2016Article
- Identification of Drosophila-based endpoints for the assessment and understanding of xenobiotic-mediated male reproductive adversities.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- The ontogeny and evolution of sex-biased gene expression in Drosophila melanogaster.Molecular biology and evolution · 2014Article
- GRASP [Genomic Resource Access for Stoichioproteomics]: comparative explorations of the atomic content of 12 Drosophila proteomes.BMC genomics · 2013Article
- Gene duplication, tissue-specific gene expression and sexual conflict in stalk-eyed flies (Diopsidae).Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Review
- Article
- Intralocus sexual conflict resolved through gene duplication.Trends in ecology & evolution · 2011Article
- Expression of ribosomal protein L22e family members in Drosophila melanogaster: rpL22-like is differentially expressed and alternatively spliced.Nucleic acids research · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Gene duplications have been broadly implicated in the generation of testis-specific genes. To perform a comprehensive analysis of paralogous testis-biased genes, we characterized the testes transcriptome of Drosophila melanogaster by comparing gene expression in testes vs. ovaries, heads, and gonadectomized males. A number of the identified 399 testis-biased genes code for the known components of mature sperm. Among the detected 69 genes downregulated in testes, a large fraction is required for viability. By analyzing paralogs of testis-biased genes, we identified "co-regulated" paralogous pairs in which both genes are testis biased, "anti-regulated" pairs in which one paralog is testis biased and the other downregulated in testes, and "neutral" pairs in which one paralog is testis biased and the other constitutively expressed. The numbers of identified co-regulated and anti-regulated pairs were higher than expected by chance. Testis-biased genes included in these pairs show decreased frequency of lethal mutations, suggesting their specific role in male reproduction. These genes also show exceptionally high interspecific variability of expression in comparison between D. melanogaster and the closely related D. simulans. Further, interspecific changes in testis bias of expression are generally correlated within the co-regulated pairs and are anti-correlated within the anti-regulated pairs, suggesting coordinated regulation within both types of paralogous gene pairs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.