ArticleGenetics2008
FER1 and FER2 encoding two ferritin complexes in Chlamydomonas reinhardtii chloroplasts are regulated by iron.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 63 citations in OpenAlex.
- Systemic acquired resistance signaling molecule N-hydroxypipecolic acid is involved in Age-related resistance in Arabidopsis thaliana.Plant physiology · 2026Article
- Chlamydomonas cells transition through distinct Fe nutrition stages within 48 h of transfer to Fe-free medium.Photosynthesis research · 2024Article
- Molecular network of the oil palm root response to aluminum stress.BMC plant biology · 2023Article
- Iron uptake, transport and storage in marine brown algae.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Review
- Long-term acclimation to cadmium exposure reveals extensive phenotypic plasticity in Chlamydomonas.Plant physiology · 2021Article
- Single-cell visualization and quantification of trace metals inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Characterization of recombinant protein ferritin fromFood science and biotechnology · 2020Article
- Regulation of Iron Homeostasis and Use in Chloroplasts.International journal of molecular sciences · 2020Review
- Different iron storage strategies among bloom-forming diatoms.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Article
- Sensitive and Selective "Turn-On" Chemodosimetric Probes for FeJournal of fluorescence · 2017Article
- Regulating cellular trace metal economy in algae.Current opinion in plant biology · 2017Review
- Identification of Reference and Biomarker Proteins in Chlamydomonas reinhardtii Cultured under Different Stress Conditions.International journal of molecular sciences · 2017Article
- The expression of heterologous Fe (III) phytosiderophore transporter HvYS1 in rice increases Fe uptake, translocation and seed loading and excludes heavy metals by selective Fe transport.Plant biotechnology journal · 2017Article
- Ostreococcus tauri is a new model green alga for studying iron metabolism in eukaryotic phytoplankton.BMC genomics · 2016Article
- Central role for ferritin in the day/night regulation of iron homeostasis in marine phytoplankton.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Chlamydomonas Genome Resource for Laboratory Strains Reveals a Mosaic of Sequence Variation, Identifies True Strain Histories, and Enables Strain-Specific Studies.The Plant cell · 2015Article
- Magnetic separation of algae genetically modified for increased intracellular iron uptake.Journal of magnetism and magnetic materials · 2015Article
- Iron sparing and recycling in a compartmentalized cell.Current opinion in microbiology · 2013Review
- Proteomic analysis of eggs from Mytilus edulis females differing in mitochondrial DNA transmission mode.Molecular & cellular proteomics : MCP · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Two unlinked genes FER1 and FER2 encoding ferritin subunits were identified in the Chlamydomonas genome. An improved FER2 gene model, built on the basis of manual sequencing and incorporation of unplaced reads, indicated 49% identity between the ferritin subunits. Both FER1 and FER2 transcripts are increased in abundance as iron nutrition is decreased but the pattern for each gene is distinct. Using subunit-specific antibodies, we monitored expression at the protein level. In response to low iron, ferritin1 subunits and the ferritin1 complex are increased in parallel to the increase in FER1 mRNA. Nevertheless, the iron content of the ferritin1 complex is decreased. This suggests that increased expression results in increased capacity for iron binding in the chloroplast of iron-limited cells, which supports a role for ferritin1 as an iron buffer. On the other hand, ferritin2 abundance is decreased in iron-deprived cells, indicative of the operation of iron-nutrition-responsive regulation at the translational or post-translational level for FER2. Both ferritin subunits are plastid localized but ferritin1 is quantitatively recovered in soluble extracts of cells while ferritin2 is found in the particulate fraction. Partial purification of the ferritin1 complex indicates that the two ferritins are associated in distinct complexes and do not coassemble. The ratio of ferritin1 to ferritin2 is 70:1 in iron-replete cells, suggestive of a more dominant role of ferritin1 in iron homeostasis. The Volvox genome contains orthologs of each FER gene, indicating that the duplication of FER genes and potential diversification of function occurred prior to the divergence of species in the Volvocales.
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