ArticleThe Journal of nutrition2008
Vitamin A concentrations in piglet extrahepatic tissues respond differently ten days after vitamin A treatment.
Article in The Journal of nutrition, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Metabolism of Neonatal Vitamin A Supplementation: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2021Pooled it
- Nutritional regulation of sow reproduction by vitamin A: insights and knowledge gaps.Porcine health management · 2026Review
- Anthocyanin and Lycopene Contents Do Not Affect β-Carotene Bioefficacy from Multicolored Carrots (Daucus carota L.) in Male Mongolian Gerbils.The Journal of nutrition · 2023Article
- Distribution of injected fat-soluble vitamins in plasma and tissues of nursery pigs.Asian-Australasian journal of animal sciences · 2020Article
- Overlapping Vitamin A Interventions with Provitamin A Carotenoids and Preformed Vitamin A Cause Excessive Liver Retinol Stores in Male Mongolian Gerbils.The Journal of nutrition · 2020Article
- Dynamics of vitamin A uptake, storage, and utilization in vocal fold mucosa.Molecular metabolism · 2020Article
- Retinol isotope dilution accurately predicts liver reserves in piglets but overestimates reserves in lactating sows.Experimental biology and medicine (Maywood, N.J.) · 2019Article
- Single High-Dose Vitamin A Supplementation to Neonatal Piglets Results in a Transient Dose Response in Extrahepatic Organs and Sustained Increases in Liver Stores.The Journal of nutrition · 2017Article
- Vitamin A Supplementation Transiently Increases Retinol Concentrations in Extrahepatic Organs of Neonatal Rats Raised under Vitamin A-Marginal Conditions.The Journal of nutrition · 2016Article
- Healthy birth weight results in higher vitamin A storage in neonate piglets administered high-dose supplements.Experimental biology and medicine (Maywood, N.J.) · 2015Article
- Interspecies comparison of stellate cell-containing macula flavae and vitamin A storage in vocal fold mucosa.Journal of anatomy · 2014Article
- α-Retinol and 3,4-didehydroretinol support growth in rats when fed at equimolar amounts and α-retinol is not toxic after repeated administration of large doses.The British journal of nutrition · 2014Article
- The retina rapidly incorporates ingested C20-D₃-vitamin A in a swine model.Molecular vision · 2013Article
- α-Retinol is distributed through serum retinol-binding protein-independent mechanisms in the lactating sow-nursing piglet dyad.The Journal of nutrition · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Periodic supplementation to infants and young children is encouraged in developing countries by the WHO. We investigated vitamin A (VA) in extrahepatic tissues of piglets after supplementation with retinyl acetate to determine long-term storage. 3, 4-Didehydroretinyl acetate (DRA) as a tracer was used to evaluate uptake from chylomicra in 4 h. Sows were fed a VA-depleted diet throughout pregnancy and lactation. Male castrated piglets (n = 28, 11.6 +/- 0.5 d) from these sows were weaned onto a VA-free diet for 1 wk, assigned to 4 groups, and dosed orally with 0, 26.2, 52.4, or 105 micromol VA. After 10 d, 5.3 micromol DRA was administered to determine short-term uptake of 3, 4-didehydroretinol (DR). Four hours later, piglets were killed; adrenal glands, kidney, lung, and spleen were collected and analyzed for retinol and DR. Retinol concentrations of kidney and adrenal gland were higher than control, but treated groups did not differ. Retinol concentration was highest in kidney (1.70-2.52 nmol/g), followed by adrenal gland (0.30-0.48 nmol/g), lung (0.15-0.21 nmol/g), and spleen (0.11-0.15 nmol/g). Total retinol in kidney and spleen was different among the groups (P < 0.05). Unesterified retinol was the major VA form; the percent retinol of total VA was lowest in adrenal glands. DR did not differ among the groups. In 4 h, the minimum estimated chylomicron contribution to tissue DR was 63-280% higher than the maximum DR exposure from retinol-binding protein. Constant dietary intake may be important in maintaining VA concentrations in extrahepatic tissues.
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Registered trials
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