ArticleThe Journal of nutrition2008
Adipocyte gene expression is altered in formerly obese mice and as a function of diet composition.
Article in The Journal of nutrition, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Ceramide-induced FGF13 impairs systemic metabolic health.Cell metabolism · 2025Article
- Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape.Nature communications · 2024Article
- Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue.Redox biology · 2022Article
- Physiological Responses of Post-Dietary Effects: Lessons from Pre-Clinical and Clinical Studies.Metabolites · 2021Review
- Do Health Promoting Compounds of Flaxseed Attenuate Weight Gain Via Modulation of Obesity Gene Expression?Plant foods for human nutrition (Dordrecht, Netherlands) · 2020Article
- Weight Regain in Formerly Obese Mice Hastens Development of Hepatic Steatosis Due to Impaired Adipose Tissue Function.Obesity (Silver Spring, Md.) · 2020Article
- Knockout of the X-linkedFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Macrophage Proliferation Sustains Adipose Tissue Inflammation in Formerly Obese Mice.Diabetes · 2017Article
- Article
- Time-course microarray analysis for identifying candidate genes involved in obesity-associated pathological changes in the mouse colon.Genes & nutrition · 2016Article
- CD11c(+) macrophages and levels of TNF-α and MMP-3 are increased in synovial and adipose tissues of osteoarthritic mice with hyperlipidaemia.Clinical and experimental immunology · 2015Article
- Isothiocyanate-rich Moringa oleifera extract reduces weight gain, insulin resistance, and hepatic gluconeogenesis in mice.Molecular nutrition & food research · 2015Article
- Menhaden oil decreases high-fat diet-induced markers of hepatic damage, steatosis, inflammation, and fibrosis in obese Ldlr-/- mice.The Journal of nutrition · 2012Article
- Differential effects of calorie restriction and exercise on the adipose transcriptome in diet-induced obese mice.Journal of obesity · 2011Article
- Distinct effects of calorie restriction and exercise on mammary gland gene expression in C57BL/6 mice.Cancer prevention research (Philadelphia, Pa.) · 2009Article
- Leucine supplementation of drinking water does not alter susceptibility to diet-induced obesity in mice.The Journal of nutrition · 2009Article
- The microbes of the intestine: an introduction to their metabolic and signaling capabilities.Endocrinology and metabolism clinics of North America · 2008Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In the development of obesity, the source of excess energy may influence appetite and metabolism. To determine the effects of differences in diet composition in obesity, mice were fed either a high-carbohydrate diet (HC; 10% fat energy) or a high-fat energy-restricted diet (HFR; 60% fat energy) over 18 wk in weight-matched groups of mice. To identify obesity-associated genes with persistently altered expression following weight reduction, mice were fed either a standard low-fat diet (LF; 10% fat energy), an unrestricted high-fat diet (HF; 60% fat energy), or a HF diet followed by weight reduction (WR). Mice fed a HF diet had significantly greater gonadal fat mass and higher whole blood glucose concentrations than mice fed an HC diet. Of the mice fed a high-fat diet, total body weight and serum insulin concentrations were greater in HF than in HFR. Microarray analysis revealed that HF vs. HC feeding resulted in global differences in adipocyte gene expression patterns. Although we identified genes whose expression was altered in both moderately and severely obese mice, there were also a large number of genes with altered expression only in severe obesity. Formerly obese, WR mice did not differ significantly from lean controls in total body weight or physiological measures. However, microarray analysis revealed distinctly different patterns of adipocyte gene expression. Furthermore, there were 398 genes with altered expression in HF mice that persisted in WR mice. Genes with persistently altered expression following obesity may play a role in rebound weight gain following weight reduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.