ArticleAmerican journal of physiology. Endocrinology and metabolism2008
Wdnm1-like, a new adipokine with a role in MMP-2 activation.
Article in American journal of physiology. Endocrinology and metabolism, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- A correctable immune niche for epithelial stem cell reprogramming and post-viral lung diseases.The Journal of clinical investigation · 2024Article
- Mouse Embryonic Fibroblast Adipogenic Potential: A Comprehensive Transcriptome Analysis.Adipocyte · 2021Article
- Uncovering the Role of p38 Family Members in Adipose Tissue Physiology.Frontiers in endocrinology · 2020Review
- Whey Acidic Protein/Four-Disulfide Core Domain 21 Regulate Sepsis Pathogenesis in a Mouse Model and a Macrophage Cell Line via the Stat3/Toll-Like Receptor 4 (TLR4) Signaling Pathway.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Cytokines and Long Noncoding RNAs.Cold Spring Harbor perspectives in biology · 2018Review
- An integrative transcriptomic approach to identify depot differences in genes and microRNAs in adipose tissues from high fat fed mice.Oncotarget · 2018Article
- lncRNAs Regulate Innate Immune Responses and Their Roles in Macrophage Polarization.Mediators of inflammation · 2018Review
- BNIP3 is essential for mitochondrial bioenergetics during adipocyte remodelling in mice.Diabetologia · 2016Article
- Transcriptional Regulation of Mononuclear Phagocyte Development.Frontiers in immunology · 2015Review
- Non-human lnc-DC orthologs encode Wdnm1-like protein.F1000Research · 2014Article
- Systems genetics of hepatocellular damage in vivo and in vitro: identification of a critical network on chromosome 11 in mouse.Physiological genomics · 2013Article
- Article
- Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism.American journal of physiology. Endocrinology and metabolism · 2012Article
- Human periprostatic adipose tissue promotes prostate cancer aggressiveness in vitro.Journal of experimental & clinical cancer research : CR · 2012Article
- Characterization of age-related gene expression profiling in bone marrow and epididymal adipocytes.BMC genomics · 2011Article
- Review
- C/EBPalpha and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor gamma agonists.Molecular and cellular biology · 2009Article
- Diet-induced obesity causes cerebral vessel remodeling and increases the damage caused by ischemic stroke.Microvascular research · 2009Article
- Three-dimensional culture models of mammary gland.Organogenesis · 2009Article
- Expression and regulation of transcript for the novel transmembrane protein Tmem182 in the adipocyte and muscle lineage.BMC research notes · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
White adipose tissue functions in energy storage and as an endocrine organ. DNA microarray analysis led us to identify Wdnm1-like, a distant member of the whey acidic protein/four-disulfide core (WAP/4-DSC) family, as a differentiation-dependent gene in white and brown adipogenesis. Wdnm1-like is a novel 6.8-kDa protein, and Western blot analysis reveals secretion into culture media. Wdnm1-like transcript is selectively expressed in adipose tissue and liver and is enriched approximately 500-fold in white adipose depots vs. brown. Cellular fractionation of WAT demonstrates Wdnm1-like transcript expression is restricted to the adipocyte population. Studies in 3T3-L1 preadipocytes, an in vitro model of white adipogenesis, indicate Wdnm1-like transcript increases within 6 h of adipogenic induction with an approximately 17,000-fold increase by day 7. Dramatic upregulation of Wdnm1-like also accompanies white adipogenesis of ScAP-23 preadipocytes and primary preadipocytes. TNF-alpha treatment of 3T3-L1 adipocytes increased Wdnm1-like transcript level 2.4-fold and was attenuated by pretreatment with the p38 MAP kinase inhibitor SB203580. A number of WAP/4-DSC family proteins function as protease inhibitors. This, taken with the role of extracellular remodeling in adipogenesis, led us to address effects of Wdnm1-like on matrix metalloproteinase (MMP) activity. Gelatin zymography of HT1080 fibrosarcoma cells transfected with a Wdnm1-like expression construct revealed markedly increased levels of active MMP-2. Our findings identify a new member of the adipocyte "secretome" that functions to enhance MMP-2 activity. We postulate that Wdnm1-like may play roles in remodeling of the extracellular milieu in adipogenesis, as well as in tumor microenvironments where adipocytes are key stromal components.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.