ArticleJournal of biomedical materials research. Part A2009
The foreign body reaction in T-cell-deficient mice.
Article in Journal of biomedical materials research. Part A, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Cyanoacrylate glue reactions: A systematic review, cases, and proposed mechanisms.Journal of vascular surgery. Venous and lymphatic disorders · 2023Pooled it
- Macrophage cell therapy enabled by interleukin-4 mRNA-loaded lipid nanoparticles to sustain a pro-reparative phenotype in inflammatory injuries.Biomaterials · 2026Article
- Foreign body reaction: towards a macrophage-centered adverse outcome pathway for fibrotic encapsulation.Frontiers in toxicology · 2026Article
- Microtopography-induced changes in cell nucleus morphology enhance bone regeneration by modulating the cellular secretome.Nature communications · 2025Article
- Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures.PLoS biology · 2025Article
- Osteoclast-like multinucleated giant cells reinforce polycaprolactone grafts.Frontiers in immunology · 2025Article
- Biodegradation of HA and β-TCP Ceramics Regulated by T-Cells.Pharmaceutics · 2022Article
- Medical Applications of Porous Biomaterials: Features of Porosity and Tissue-Specific Implications for Biocompatibility.Advanced healthcare materials · 2022Review
- Foreign body response to synthetic polymer biomaterials and the role of adaptive immunity.Biomedical materials (Bristol, England) · 2022Review
- Implant Fibrosis and the Underappreciated Role of Myofibroblasts in the Foreign Body Reaction.Cells · 2021Review
- Efficient and Consistent Orthotopic Osteosarcoma Model by Cell Sheet Transplantation in the Nude Mice for Drug Testing.Frontiers in bioengineering and biotechnology · 2021Article
- Immunomodulation for maxillofacial reconstructive surgery.Maxillofacial plastic and reconstructive surgery · 2020Review
- Aseptic Ligatures Induce Marginal Peri-Implant Bone Loss-An 8-Week Trial in Rabbits.Journal of clinical medicine · 2019Article
- Mesenchymal stem cell-based bioengineered constructs: foreign body response, cross-talk with macrophages and impact of biomaterial design strategies for pelvic floor disorders.Interface focus · 2019Review
- Biocompatibility of common implantable sensor materials in a tumor xenograft model.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Article
- Characterization of the T-cell response to polypropylene mesh in women with complications.American journal of obstetrics and gynecology · 2019Article
- Engineering of an angiogenic niche by perfusion culture of adipose-derived stromal vascular fraction cells.Scientific reports · 2017Article
- Non-classical monocytes are biased progenitors of wound healing macrophages during soft tissue injury.Scientific reports · 2017Article
- Mutant CCL2 protein coating mitigates wear particle-induced bone loss in a murine continuous polyethylene infusion model.Biomaterials · 2017Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The role(s) of T lymphocytes in the foreign body response has not been thoroughly elucidated. Lymphocytes are known to augment macrophage adhesion and fusion in vitro. Furthermore, T lymphocytes are a possible source of the cytokines, IL-4 and IL-13, which induce macrophage fusion. In this study, we used BALB/c mice and BALB/c (nu/nu) nude mice to investigate foreign body giant cell (FBGC) formation in a T-cell-deficient setting. Mice were implanted with Elasthane 80A (PEU), silicone rubber (SR), or poly(ethylene terephthalate) (PET) for 7, 14, or 21 days using the cage implant system. Exudate cells and IL-4 and IL-13 levels in exudate supernatants were analyzed by flow cytometry and a multiplex immunoassay, respectively, at Days 7, 14, and 21. Macrophage adhesion and fusion on material surfaces were analyzed using optical microscopy. T-cell-deficient mice had lower total leukocyte concentrations at the biomaterial implant site at all time points. Adherent cell density was comparable between normal and T-cell-deficient mice except in the PEU group at Day 21. However, percent fusion, average nuclei per FBGC, and FBGC morphology were comparable between normal and T-cell-deficient mice. IL-4 was not detected in any sample, but IL-13 levels were also comparable between normal and T-cell-deficient mice indicating Th2-polarized T-cells are not the sole source of this cytokine. We have shown that there are pathways that do not require thymus-matured T lymphocytes, which lead to a normal foreign body response to biomaterials in a murine model.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.