ReviewHormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme2008
Current progress and future challenges in the biochemical diagnosis and treatment of pheochromocytomas and paragangliomas.
Review in Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.
- 7th Brazilian Guideline of Arterial Hypertension: Chapter 12 - Secondary Arterial HypertensionArquivos brasileiros de cardiologia · 2016Guideline
- Pseudopheochromocytoma: an Uncommon Cause of Severe Hypertension.Current cardiology reports · 2022Review
- The noradrenergic profile of plasma metanephrine in neuroblastoma patients is reproduced in xenograft mice models and arise from PNMT downregulation.Oncotarget · 2021Article
- Volume-outcome correlation in adrenal surgery-an ESES consensus statement.Langenbeck's archives of surgery · 2019Review
- Retroperitoneal paraganglioma: a chameleon masquerading as an adrenal pheochromocytoma.Annals of the Royal College of Surgeons of England · 2019Article
- Clinical, Diagnostic, and Treatment Characteristics ofFrontiers in oncology · 2019Article
- Case - Bladder paraganglioma in a pediatric patient.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2018Article
- Current diagnostic imaging of pheochromocytomas and implications for therapeutic strategy.Experimental and therapeutic medicine · 2018Article
- QuantitativeEuropean journal of nuclear medicine and molecular imaging · 2018Article
- Effects of Trilostane on urinary Catecholamines and their metabolites in dogs with Hypercortisolism.BMC veterinary research · 2017Article
- Multimodal Somatostatin Receptor Theranostics Using [(64)Cu]Cu-/[(177)Lu]Lu-DOTA-(Tyr(3))octreotate and AN-238 in a Mouse Pheochromocytoma Model.Theranostics · 2016Article
- Pheochromocytoma after Cesarean Section.International journal of preventive medicine · 2016Article
- Development and validation of liquid chromatography-tandem mass spectrometry method for quantification of plasma metanephrines for differential diagnosis of adrenal incidentaloma.Annals of laboratory medicine · 2015Article
- Protocol for the examination of specimens from patients with pheochromocytomas and extra-adrenal paragangliomas.Archives of pathology & laboratory medicine · 2014Article
- Hypertension in a teenager: a family affair.BMJ case reports · 2014Article
- Current and future treatments for malignant pheochromocytoma and sympathetic paraganglioma.Current oncology reports · 2013Review
- Pheochromocytoma/Paraganglioma: Review of perioperative management of blood pressure and update on genetic mutations associated with pheochromocytoma.Journal of clinical hypertension (Greenwich, Conn.) · 2013Review
- Anti-tumor effects of peptide analogs targeting neuropeptide hormone receptors on mouse pheochromocytoma cells.Molecular and cellular endocrinology · 2013Article
- Inherited mutations in pheochromocytoma and paraganglioma: why all patients should be offered genetic testing.Annals of surgical oncology · 2013Article
- Role of helicity on the anticancer mechanism of action of cationic-helical peptides.International journal of molecular sciences · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Findings from five independent studies - with close to 350 patients with pheochromocytoma and more than 2,500 in whom the tumor was excluded - indicate that measurements of plasma free metanephrines provide an overall diagnostic sensitivity of 98% and specificity of 92%. The recommendation that initial testing for the tumor should always include measurements of either plasma or urinary fractionated metanephrines results from recognition of the high diagnostic sensitivity of measurements of plasma metanephrines. The few patients with pheochromocytoma in whom the test may not yield a positive result include those with very small tumors or microscopic disease and others with tumors that do not produce norepinephrine and epinephrine. Such patients are typically normotensive and do not exhibit symptoms of catecholamine excess. Additional measurements of methoxytyramine can be useful for detecting those tumors that produce only dopamine. Suboptimal diagnostic specificity and difficulties in distinguishing true- from false-positive elevations of plasma metanephrines remain challenges for diagnosis. Improvements in analytical technology (e.g., liquid chromatography with tandem mass spectrometry) and new strategies for follow-up testing provide possible solutions to these problems. The single most important remaining clinical care challenge is the development of effective cures for patients with malignant disease. Current treatments, none of which are truly satisfactory, include chemotherapy and radiopharmaceutical therapy with (131)I-labelled M-iodobenzylguanidine or radioactive somatostatin analogues. Improvements in treatment may in the future come from several fronts, but proof of efficacy ideally will require well-coordinated multicenter prospective trials in larger numbers of patients than in previous studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.