Evidence map›Paper›PMID 18491170›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2008

Screening for undiagnosed diabetes in patients with acute myocardial infarction.

Mark Lankisch, Reiner Füth, Hartmut Gülker, Harald Lapp, Alexander Bufe, Burkhard Haastert, Stephan Martin, Wolfgang Rathmann

Abstract readControlled Clinical Trial
PubMed Publisher
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Observational
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  5. Observational
  6. Review
  7. Review
  8. Article
  9. Review
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  11. Article
  12. Admission glucose level and in-hospital outcomes in diabetic and non-diabetic patients with acute myocardial infarction.Clinical research in cardiology : official journal of the German Cardiac Society · 2010
    Article
  13. Article
  14. Article
  15. Hotline update of clinical trials and registries presented at the German Cardiac Society Meeting 2009.Clinical research in cardiology : official journal of the German Cardiac Society · 2009
    Review
  16. Article
  17. Treatment of patients with diabetes with GLP-1 analogues or DPP-4- inhibitors: a hot topic for cardiologists?Clinical research in cardiology : official journal of the German Cardiac Society · 2009
    Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Mark LankischGerman Diabetes Center, Heinrich Heine University, Düsseldorf, Germany.
Reiner Füth
Hartmut Gülker
Harald Lapp
Alexander Bufe
Burkhard Haastert
Stephan Martin
Wolfgang Rathmann
Deutsches Diabetes-Zentrum e.V. · DEHeinrich Heine University Düsseldorf · DEHelios Kliniken · DEHelios Klinikum Erfurt · DEHelios Universitätsklinikum Wuppertal · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundScreening for undiagnosed diabetes in patients with acute myocardial infarction is recommended (ESC and EASD Task Force 2007). Glucose tolerance testing in the peri-infarct period may not be valid because of confounding, e.g. by the acute stress reaction. The aim was to evaluate undiagnosed diabetes (DM) and impaired glucose regulation (IGR) in AMI during hospital stay and 3 months after discharge. MATERIALS AND

methodsIn 96 consecutively admitted AMI patients (Heart Center Wuppertal, Germany) OGTT were performed, of whom in 62 OGTT were also carried out 3 months later.

resultsBefore discharge 32% of the patients had newly diagnosed diabetes and 47% patients had prediabetes (IGR). Glucose tolerance was normal in 20 (21%) patients only. After 3 months, 74% with newly diagnosed DM at baseline still had disturbed glucose metabolism (58% DM, 16% IGT). No patient with normal OGTT became diabetic after 3 months. In multivariate regression, the odds of having diabetes (3 months) was about sixfold higher when having diabetes before discharge (OGTT). Admission glucose, infarction size CK(MAX), and inflammation (CRP) were not significantly related to OGTT results.

conclusionsThis prospective study confirms a high prevalence of undiagnosed DM in patients with AMI. In about 60% of AMI patients, newly diagnosed DM persisted after 3 months. For the first time we could show that there is no correlation between infarction size and undiagnosed diabetes. Thus, an OGTT performed before discharge may provide a reliable measure of disturbed glucose regulation but needs to be repeated.

Indexed as

AgedComorbidityDiabetes MellitusFemaleGermanyGlucose Tolerance TestHumansMaleMass ScreeningMiddle AgedMyocardial InfarctionPrevalenceReproducibility of ResultsRisk AssessmentRisk FactorsSensitivity and Specificity

Identifiers

PMID18491170
OpenAlexW1975464745

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.