Evidence map›Paper›PMID 18490916›Full record

ReviewNature reviews. Neuroscience2008

The neural control of micturition.

Clare J Fowler, Derek Griffiths, William C de Groat

6 registry-linked trialsOpen access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 621 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
621citing papers in PubMed, 5 pooled it
38.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04516434 nacompletednot on this mapstarted 2021, after this paper: background citation

AMPLIFY: Amplifying Sensation in Underactive Bladder

TypeinterventionalSponsorDuke UniversityRan2021 to 2024Enrolled20ConditionsUrinary Bladder, UnderactiveArmsNeurometer Neurotron CPT, Cystometry, Pressure-flow study
NCT05075642 unknown statusnot on this mapstarted 2021, after this paper: background citation

A Multicentre Observational Study for the Evaluation in Clinical Practice of the Initial Diagnostic-therapeutic Path of Urinary Disorders in Multiple Sclerosis

TypeobservationalSponsorASP 7 RagusaRan2021 to 2023Enrolled214ConditionsMultiple Sclerosis, Urinary Bladder, NeurogenicArmsInitial management of the urinary disorder/s identified during the screening phase
NCT05485142 naunknown statusnot on this mapstarted 2019, after this paper: background citation

The Treatment Efficacy of Prolotherapy in Bladder Voiding Dysfunction

TypeinterventionalSponsorTaichung Armed Forces General HospitalRan2019 to 2024Enrolled80ConditionsOveractive Bladder, Underactive BladderArmsprolotherapy
NCT05880602 nacompletednot on this mapstarted 2023, after this paper: background citation

Clinical Trial of Nettle and Cranberry Capsules for Prevention of Urinary Tract Infection

TypeinterventionalSponsorChung Shan Medical UniversityRan2023 to 2023Enrolled60ConditionsUrinary Tract InfectionArmsNettle and Cranberry complex capsules, Placebo(starch)
NCT05989646 narecruitingnot on this mapstarted 2021, after this paper: background citation

Brain Activity Among Children With Overactive Bladder and Daytime Urinary Incontinence and Healthy Children, and Modulation of Brain Activity by Transcutaneous Electrical Nerve Stimulation - a Functional Magnetic Resonance Imaging Study

TypeinterventionalSponsorAalborg University HospitalRan2021 to 2027Enrolled65ConditionsUrinary Incontinence, Daytime Wetting, Urination Disorders, Urination InvoluntaryArmsSacral TENS
NCT06587841 narecruitingnot on this mapstarted 2024, after this paper: background citation

Noninvasive Spinal Cord Neuromodulation to Improve Lower Urinary Tract Function After Spinal Cord Injury in Ukrainian War Veterans

TypeinterventionalSponsorUniversity of British ColumbiaRan2024 to 2027Enrolled60ConditionsSpinal Cord Injuries, Bowel Dysfunction, Sexual Dysfunction, Autonomic DysfunctionArmsSpinal COrd NEuromodulation™ (SCONE™) for transcutaneous spinal cord stimulation (TSCS)
3 · Its place in the literature

Who cites it

621 citing papers in PubMed, 5 syntheses or guidelines pooled it, 1,425 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Effects of Robot-Assisted Gait Therapy on Urodynamic Changes in the Subacute Phase After Spinal Cord Injury: A Prospective Study.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Trial
  7. Trial
  8. Trial
  9. Article
  10. Article
  11. Review
  12. Letter to the editor concerning "Neuromodulatory effects of repetitive transcranial magnetic stimulation on post-stroke urinary retention: insights from neuroelectrophysiological assessment".Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review

561 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Clare J FowlerUniversity College London, Department of Uro-Neurology, London, WC1N 3BG, UK. c.fowler@ion.ucl.ac.uk
Derek Griffiths
William C de Groat
University College London · GBUniversity of Pittsburgh · USUniversity of Pittsburgh Medical Center · US

Funding

AFFERENT MECHANISMS UNDERLYING BLADDER PAINR37DK049430 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DEGROAT, WILLIAM C · 2000 to 2009
$3.0M
Neuroplasticity of Urinary Tract Disorders after SCIR01DK077783 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DEGROAT, WILLIAM C · 2007 to 2010
$1.2M
AFFERENT MECHANISMS UNDERLYING BLADDER PAINR01DK049430 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DEGROAT, WILLIAM C · 1994 to 1998
–
NIDDK NIH HHS DK049430NIDDK NIH HHS DK077783NIDDK NIH HHS R01 DK049430NIDDK NIH HHS R01 DK077783NIDDK NIH HHS R37 DK049430
6 · The paper itself

Abstract

Micturition, or urination, occurs involuntarily in infants and young children until the age of 3 to 5 years, after which it is regulated voluntarily. The neural circuitry that controls this process is complex and highly distributed: it involves pathways at many levels of the brain, the spinal cord and the peripheral nervous system and is mediated by multiple neurotransmitters. Diseases or injuries of the nervous system in adults can cause the re-emergence of involuntary or reflex micturition, leading to urinary incontinence. This is a major health problem, especially in those with neurological impairment. Here we review the neural control of micturition and how disruption of this control leads to abnormal storage and release of urine.

Indexed as

Nervous System Physiological PhenomenaAnimalsHumansNervous System DiseasesNeural PathwaysNeurotransmitter AgentsTrauma, Nervous SystemUrinary IncontinenceUrinationNeurotransmitter Agents

Identifiers

PMID18490916
PMCPMC2897743
OpenAlexW2008969125

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.