ArticleJournal of immunology (Baltimore, Md. : 1950)2008
Suppressive oligodeoxynucleotides inhibit silica-induced pulmonary inflammation.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- DNA-based hydrogels for bone regeneration: A promising tool for bone organoids.Materials today. Bio · 2025Review
- A toxicological profile of silica nanoparticles.Toxicology research · 2022Review
- RNA-seq-Based Screening in Coal Dust-Treated Cells IdentifiedBioMed research international · 2021Article
- Tobacco Smoke Exposure Exacerbated Crystalline Silica-Induced Lung Toxicity in Rats.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Cytotoxic effects of dental prosthesis grinding dust on RAW264.7 cells.Scientific reports · 2020Article
- An In Vitro Lung System to Assess the Proinflammatory Hazard of Carbon Nanotube Aerosols.International journal of molecular sciences · 2020Article
- Silicosis and lung cancer: current perspectives.Lung Cancer (Auckland, N.Z.) · 2018Review
- Suppressive oligonucleotides inhibit inflammation in a murine model of mechanical ventilator induced lung injury.Journal of thoracic disease · 2016Article
- Use of nanoparticles to deliver immunomodulatory oligonucleotides.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2016Review
- Structure, mechanism and therapeutic utility of immunosuppressive oligonucleotides.Pharmacological research · 2016Review
- Cell-Based Therapy for Silicosis.Stem cells international · 2016Review
- Silica particles cause NADPH oxidase-independent ROS generation and transient phagolysosomal leakage.Molecular biology of the cell · 2015Article
- Article
- Suppressive oligodeoxynucleotides reduce lung cancer susceptibility in mice with silicosis.Carcinogenesis · 2014Article
- Synthetic oligodeoxynucleotides containing suppressive TTAGGG motifs inhibit AIM2 inflammasome activation.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Suppressive oligodeoxynucleotides synergistically enhance antiproliferative effects of anticancer drugs in A549 human lung cancer cells.International journal of oncology · 2013Article
- Class I/II hybrid inhibitory oligodeoxynucleotide exerts Th1 and Th2 double immunosuppression.FEBS open bio · 2013Article
- Article
- Overexpression of apolipoprotein A1 in the lung abrogates fibrosis in experimental silicosis.PloS one · 2013Article
- Transcriptomics analysis of lungs and peripheral blood of crystalline silica-exposed rats.Inhalation toxicology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Inhalation of silica-containing dust particles induces silicosis, an inflammatory disease of the lungs characterized by the infiltration of macrophages and neutrophils into the lungs and the production of proinflammatory cytokines, chemokines, and reactive oxygen species (ROS). Synthetic oligodeoxynucleotides (ODN) expressing "immunosuppressive motifs" were recently shown to block pathologic inflammatory reactions in murine models of autoimmune disease. Based on those findings, the potential of suppressive ODN to prevent acute murine silicosis was examined. In vitro studies indicate that suppressive ODN blunt silica-induced macrophage toxicity. This effect was associated with a reduction in ROS production and p47phox expression (a subunit of NADPH oxidase key to ROS generation). In vivo studies show that pretreatment with suppressive (but not control) ODN reduces silica-dependent pulmonary inflammation, as manifest by fewer infiltrating cells, less cytokine/chemokine production, and lower levels of ROS (p < 0.01 for all parameters). Treatment with suppressive ODN also reduced disease severity and improved the survival (p < 0.05) of mice exposed to silica.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.