ArticleJournal of immunology (Baltimore, Md. : 1950)2008
CD43 regulates Th2 differentiation and inflammation.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Mechanism of isorhynchophylline in lipopolysaccharide-induced acute lung injury based on proteomic technology.Frontiers in pharmacology · 2024Article
- Targeting CD43 optimizes cancer immunotherapy through reinvigorating antitumor immune response in colorectal cancer.Cellular oncology (Dordrecht, Netherlands) · 2023Article
- CD43 sialoglycoprotein modulates cardiac inflammation and murine susceptibility to Trypanosoma cruzi infection.Scientific reports · 2019Article
- Sialomucin CD43 regulates T helper type 17 cell intercellular adhesion molecule 1 dependent adhesion, apical migration and transendothelial migration.Immunology · 2019Article
- The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Increased mortality in CD43-deficient mice during sepsis.PloS one · 2018Article
- Engagement of distinct epitopes on CD43 induces different co-stimulatory pathways in human T cells.Immunology · 2016Article
- CD43 Functions as an E-Selectin Ligand for Th17 Cells In Vitro and Is Required for Rolling on the Vascular Endothelium and Th17 Cell Recruitment during Inflammation In Vivo.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Article
- Epigenomic elements enriched in the promoters of autoimmunity susceptibility genes.Epigenetics · 2014Article
- DNA methylation changes separate allergic patients from healthy controls and may reflect altered CD4+ T-cell population structure.PLoS genetics · 2014Article
- CD43-mediated IFN-γ production by CD8+ T cells promotes abdominal aortic aneurysm in mice.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- CD43 interaction with ezrin-radixin-moesin (ERM) proteins regulates T-cell trafficking and CD43 phosphorylation.Molecular biology of the cell · 2011Article
- Age-related defects in the cytoskeleton signaling pathways of CD4 T cells.Ageing research reviews · 2011Review
- Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma.Respiratory research · 2009Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
CD43 is a highly glycosylated transmembrane protein that regulates T cell activation. CD43(-/-) T cells are hyperproliferative and the cytoplasmic tail of CD43 has been found to be sufficient to reconstitute wild-type proliferation levels, suggesting an intracellular mechanism. In this study, we report that upon TCR ligation CD43(-/-) T cells demonstrated no increase in tyrosine phosphorylation but a decreased calcium flux. Interestingly, CD43(-/-) T cells preferentially differentiated into Th2 cells in vitro, and CD43(-/-) T cells show increased GATA-3 translocation into the nucleus. In vivo, CD43(-/-) mice exhibited increased inflammation in two separate models of Th2-mediated allergic airway disease. In contrast, in Th1-mediated diabetes, nonobese diabetic CD43(-/-) mice did not significantly differ from wild-type mice in disease onset or progression. Th1-induced experimental autoimmune encephalomyelitis to MOG(35-55) was also normal in the CD43(-/-) mice. Nonetheless, the CD43(-/-) mice produced more IL-5 when restimulated with MOG(35-55) in vitro and demonstrated decreased delayed-type hypersensitivity responses. Together, these data demonstrate that although CD43(-/-) T cells preferentially differentiate into Th2 cells, this response is not sufficient to protect against Th1-mediated autoimmune responses.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.