SynthesisCirculation2008
Risk/benefit assessment of beta-blockers and diuretics precludes their use for first-line therapy in hypertension.
Synthesis in Circulation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic Review on the Efficacy of Atenolol in Antihypertensive Treatment: Recommendation from the Brazilian Society of Cardiology.Arquivos brasileiros de cardiologia · 2025Pooled it
- Beta-blockers for preventing stroke recurrence.The Cochrane database of systematic reviews · 2014Pooled it
- Guideline-directed antihypertensive medication use among young adult participants with uncontrolled hypertension at enrollment in the MyHEART study.BMC cardiovascular disorders · 2024Trial
- Potassium Magnesium Citrate Is Superior to Potassium Chloride in Reversing Metabolic Side Effects of Chlorthalidone.Hypertension (Dallas, Tex. : 1979) · 2023Trial
- Is diabetes mellitus-linked amino acid signature associated with β-blocker-induced impaired fasting glucose?Circulation. Cardiovascular genetics · 2014Trial
- PROX1 gene variant is associated with fasting glucose change after antihypertensive treatment.Pharmacotherapy · 2014Trial
- Adding thiazide to a renin-angiotensin blocker improves left ventricular relaxation and improves heart failure in patients with hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2012Trial
- ALLHAT findings revisited in the context of subsequent analyses, other trials, and meta-analyses.Archives of internal medicine · 2009Trial
- Pharmacogenomics of antihypertensive drugs: rationale and design of the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) study.American heart journal · 2009Trial
- Changes in serum potassium mediate thiazide-induced diabetes.Hypertension (Dallas, Tex. : 1979) · 2008Trial
- Natural Alkaloids as Antimicrobial Agents: Mechanisms, Potentials and Challenges.Molecules (Basel, Switzerland) · 2026Review
- Comparison of all-cause and cause-specific mortality after myocardial infarction - a Hungarian registry study.American heart journal plus : cardiology research and practice · 2025Article
- Diuretics in patients with chronic kidney disease.Nature reviews. Nephrology · 2025Review
- Double-Trouble: Atherosclerotic Risk Factors and Congenital Heart Disease.Current atherosclerosis reports · 2023Review
- The role of dietary salt in metabolism and energy balance: Insights beyond cardiovascular disease.Diabetes, obesity & metabolism · 2023Review
- The link among microbiota, epigenetics, and disease development.Environmental science and pollution research international · 2021Review
- Stress-Induced Hyperglycaemia in Non-Diabetic Patients with Acute Coronary Syndrome: From Molecular Mechanisms to New Therapeutic Perspectives.International journal of molecular sciences · 2021Review
- Pediatric Obesity, Hypertension, Lipids.Current treatment options in pediatrics · 2020Article
- A review of the prescribing trend of thiazide-type and thiazide-like diuretics in hypertension: A UK perspective.British journal of clinical pharmacology · 2019Review
- Observational
Corrections and comments
- Comment on
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
18490538What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.