ArticleThe Journal of cell biology2008
Similar active genes cluster in specialized transcription factories.
Article in The Journal of cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed.
- A misplaced lncRNA causes brachydactyly in humans.The Journal of clinical investigation · 2012Trial
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- The role of transcription bodies in gene expression: what embryos teach us.Biochemical Society transactions · 2025Review
- Episomes and Transposases-Utilities to Maintain Transgene Expression from Nonviral Vectors.Genes · 2022Review
- Live imaging of transcription sites using an elongating RNA polymerase II-specific probe.The Journal of cell biology · 2022Article
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- Phase separation drives pairing of homologous chromosomes.Current genetics · 2020Review
- Mechanism of Long-Range Chromosome Motion Triggered by Gene Activation.Developmental cell · 2020Article
- Chromosome-associated RNA-protein complexes promote pairing of homologous chromosomes during meiosis in Schizosaccharomyces pombe.Nature communications · 2019Article
- Hormone-control regions mediate steroid receptor-dependent genome organization.Genome research · 2019Article
- Genome-wide profiling of S/MAR-based replicon contact sites.Nucleic acids research · 2017Article
- Superresolution imaging of nanoscale chromosome contacts.Scientific reports · 2017Article
- Binding of nuclear factor κB to noncanonical consensus sites reveals its multimodal role during the early inflammatory response.Genome research · 2016Article
- Simulating topological domains in human chromosomes with a fitting-free model.Nucleus (Austin, Tex.) · 2016Article
- Organization of nuclear architecture during adipocyte differentiation.Nucleus (Austin, Tex.) · 2016Review
- Phase Behavior of DNA in the Presence of DNA-Binding Proteins.Biophysical journal · 2016Article
- Article
- Article
- Functional chromatin features are associated with structural mutations in cancer.BMC genomics · 2014Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How transcription affects the way specific genes are arranged within the nucleus remains to be fully understood. We examine here whether transcription occurs in discrete sites (factories) containing the required machinery and whether these sites specialize in transcribing different genes. We cotransfected plasmids encoding a common origin of replication but different transcription units into cells, where they are assembled into minichromosomes that the cellular machinery replicates and transcribes. In cells containing thousands of minichromosomes, we found (using fluorescence in situ hybridization) active templates concentrated in only a few factories that transcribe particular units depending on the promoter type and the presence of an intron. Close proximity between similar transcription units, whether on two different minichromosomes or on host chromosomes and minichromosomes, is confirmed using chromosome conformation capture. We conclude that factories specialize in producing a particular type of transcript depending on promoter type and whether or not the gene contains an intron.
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