ArticleInfection and immunity2008
Pneumocystis murina infection and cigarette smoke exposure interact to cause increased organism burden, development of airspace enlargement, and pulmonary inflammation in mice.
Article in Infection and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 57 citations in OpenAlex.
- Article
- Camel milk inhibits pulmonary oxidative stress and inflammation in a rat model of COPD induced by cigarette smoke exposure.Heliyon · 2024Article
- Clinical Characteristics and Prognostic Predictors of PneumocystisInfection and drug resistance · 2024Article
- Article
- Effects of repeated infections with non-typeable Haemophilus influenzae on lung in vitamin D deficient and smoking mice.Respiratory research · 2022Article
- Role ofExperimental and therapeutic medicine · 2020Article
- The mammalian mycobiome: A complex system in a dynamic relationship with the host.Wiley interdisciplinary reviews. Systems biology and medicine · 2019Review
- A Molecular Window into the Biology and Epidemiology of Pneumocystis spp.Clinical microbiology reviews · 2018Review
- The role of acute and chronic respiratory colonization and infections in the pathogenesis of COPD.Respirology (Carlton, Vic.) · 2017Review
- Review
- Lung cancer in persons with HIV.Current opinion in HIV and AIDS · 2017Review
- The respiratory microbiome of HIV-infected individuals.Expert review of anti-infective therapy · 2016Review
- Lung Malignancies in HIV Infection.Seminars in respiratory and critical care medicine · 2016Review
- The Human Microbiome in the Lung: Are Infections Contributing to Lung Health and Disease?Chronic obstructive pulmonary diseases (Miami, Fla.) · 2016Article
- Factors associated with abnormal spirometry among HIV-infected individuals.AIDS (London, England) · 2015Article
- Topographic diversity of the respiratory tract mycobiome and alteration in HIV and lung disease.American journal of respiratory and critical care medicine · 2015Article
- The microbiome and the lung.Annals of the American Thoracic Society · 2014Review
- Infections in the immunosuppressed host.Annals of the American Thoracic Society · 2014Review
- Trimethoprim-sulfamethoxazole treatment does not reverse obstructive pulmonary changes in pneumocystis-colonized nonhuman primates with SHIV infection.Journal of acquired immune deficiency syndromes (1999) · 2014Article
- Pneumocystis jirovecii colonization is associated with enhanced Th1 inflammatory gene expression in lungs of humans with chronic obstructive pulmonary disease.Microbiology and immunology · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Chronic obstructive pulmonary disease (COPD) is characterized by the presence of airflow obstruction and lung destruction with airspace enlargement. In addition to cigarette smoking, respiratory pathogens play a role in pathogenesis, but specific organisms are not always identified. Recent reports demonstrate associations between the detection of Pneumocystis jirovecii DNA in lung specimens or respiratory secretions and the presence of emphysema in COPD patients. Additionally, human immunodeficiency virus-infected individuals who smoke cigarettes develop early emphysema, but a role for P. jirovecii in pathogenesis remains speculative. We developed a new experimental model using immunocompetent mice to test the interaction of cigarette smoke exposure and environmentally acquired Pneumocystis murina infection in vivo. We hypothesized that cigarette smoke and P. murina would interact to cause increases in total lung capacity, airspace enlargement, and pulmonary inflammation. We found that exposure to cigarette smoke significantly increases the lung organism burden of P. murina. Pulmonary infection with P. murina, combined with cigarette smoke exposure, results in changes in pulmonary function and airspace enlargement characteristic of pulmonary emphysema. P. murina and cigarette smoke exposure interact to cause increased lung inflammatory cell accumulation. These findings establish a novel animal model system to explore the role of Pneumocystis species in the pathogenesis of COPD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.