ReviewBrain : a journal of neurology2008
The complex genetics of multiple sclerosis: pitfalls and prospects.
Review in Brain : a journal of neurology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Network-based multiple sclerosis pathway analysis with GWAS data from 15,000 cases and 30,000 controls.American journal of human genetics · 2013Pooled it
- [Alemtuzumab-induced Graves' disease].Problemy endokrinologii · 2023Article
- Review
- Identification of Potential Inflammation-Related Genes and Key Pathways Associated with Complex Regional Pain Syndrome.Biomolecules · 2023Article
- Optical coherence tomography assessment of axonal and neuronal damage of the retina in patients with familial and sporadic multiple sclerosis.Frontiers in neurology · 2022Article
- Article
- Genomic, proteomic, and systems biology approaches in biomarker discovery for multiple sclerosis.Cellular immunology · 2020Review
- Biomarkers in Multiple Sclerosis.Cold Spring Harbor perspectives in medicine · 2019Review
- The Genetics of Multiple Sclerosis: From 0 to 200 in 50 Years.Trends in genetics : TIG · 2017Review
- Article
- Prevalence and Incidence of Multiple Sclerosis in Tehran, Iran.Iranian journal of public health · 2017Article
- Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis.Nature reviews. Neurology · 2017Review
- The influence of gut-derived CD39 regulatory T cells in CNS demyelinating disease.Translational research : the journal of laboratory and clinical medicine · 2017Review
- Heterogeneous Network Edge Prediction: A Data Integration Approach to Prioritize Disease-Associated Genes.PLoS computational biology · 2015Article
- The gut microbiome in multiple sclerosis.Current treatment options in neurology · 2015Article
- Gut microbiome and the risk factors in central nervous system autoimmunity.FEBS letters · 2014Review
- Defining a new biomarker for the autoimmune component of Multiple Sclerosis: Th40 cells.Journal of neuroimmunology · 2014Article
- Clinical, MRI, and CSF markers of disability progression in multiple sclerosis.Disease markers · 2013Review
- Progress in multiple sclerosis genetics.Current genomics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The genetics of complex disease is entering a new and exciting era. The exponentially growing knowledge and technological capabilities emerging from the human genome project have finally reached the point where relevant genes can be readily and affordably identified. As a result, the last 12 months has seen a virtual explosion in new knowledge with reports of unequivocal association to relevant genes appearing almost weekly. The impact of these new discoveries in Neuroscience is incalculable at this stage but potentially revolutionary. In this review, an attempt is made to illuminate some of the mysteries surrounding complex genetics. Although focused almost exclusively on multiple sclerosis all the points made are essentially generic and apply equally well, with relatively minor addendums, to any other complex trait, neurological or otherwise.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.