ArticleBMC cell biology2008
Comparative study of mesenchymal stem cells from C57BL/10 and mdx mice.
Article in BMC cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Labeling and Tracking of Individual Human Mesenchymal Stromal Cells Using Photoconvertible Fluorescent Microcapsules.International journal of molecular sciences · 2023Article
- DP71 and SERCA2 alteration in human neurons of a Duchenne muscular dystrophy patient.Stem cell research & therapy · 2019Article
- Mesenchymal Stem Cells of Different Origin-Seeded Bioceramic Construct in Regeneration of Bone Defect in Rabbit.Tissue engineering and regenerative medicine · 2018Article
- Mesenchymal stem cells as cellular vectors for pediatric neurological disorders.Brain research · 2014Review
- Evaluation of neural damage in Duchenne muscular dystrophy patients.Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology · 2014Article
- Enhancing the efficacy of mesenchymal stem cell therapy.World journal of stem cells · 2014Review
- Isolation, characterization and the multi-lineage differentiation potential of rabbit bone marrow-derived mesenchymal stem cells.Journal of anatomy · 2013Article
- Transgene expression and differentiation of baculovirus-transduced adipose-derived stem cells from dystrophin-utrophin double knock-out mouse.Neural regeneration research · 2012Article
- Cellular mechanism underlying the facilitation of contractile response of vas deferens smooth muscle by sodium orthovanadate.Molecular and cellular biochemistry · 2012Article
- Atmospheric oxygen inhibits growth and differentiation of marrow-derived mouse mesenchymal stem cells via a p53-dependent mechanism: implications for long-term culture expansion.Stem cells (Dayton, Ohio) · 2012Article
- CD45-CD14 +CD34 + murine bone marrow low-adherent mesenchymal primitive cells preserve multilineage differentiation potential in long-term in vitro culture.Molecules and cells · 2011Article
- Stromal cell-derived factors in Duchenne muscular dystrophy.Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology · 2010Article
- Cell growth characteristics, differentiation frequency, and immunophenotype of adult ear mesenchymal stem cells.Stem cells and development · 2010Article
- Mesenchymal stem cells: emerging therapy for Duchenne muscular dystrophy.PM & R : the journal of injury, function, and rehabilitation · 2009Review
- Muscular dystrophy therapy by nonautologous mesenchymal stem cells: muscle regeneration without immunosuppression and inflammation.Transplantation · 2009Article
- Comparative characterization of mesenchymal stem cells from eGFP transgenic and non-transgenic mice.BMC cell biology · 2009Article
- Ultrastructure Morphological Characterization of Different Passages of Rat Dental Follicle Stem Cells atJournal of microscopy and ultrastructureArticle
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman mesenchymal stem cells (MSCs) have been studied and applied extensively because of their ability to self-renew and differentiate into various cell types. Since most human diseases models are murine, mouse MSCs should have been studied in detail. The mdx mouse - a Duchenne muscular dystrophy model - was produced by introducing a point mutation in the dystrophin gene. To understand the role of dystrophin in MSCs, we compared MSCs from mdx and C57BL/10 mice, focusing particularly on the aspects of light and electron microscopic morphology, immunophenotyping, and differentiation potential.
resultsOur study showed that at passage 10, mdx-MSCs exhibited increased heterochromatin, larger vacuoles, and more lysosomes under electron microscopy compared to C57BL/10-MSCs. C57BL/10-MSCs formed a few myotubes, while mdx-MSCs did not at the same passages. By passage 21, mdx-MSCs but not C57BL/10-MSCs had gradually lost their proliferative ability. In addition, a significant difference in the expression of CD34, not Sca-1 and CD11b, was observed between the MSCs from the 2 mice.
conclusionOur current study reveals that the MSCs from the 2 mice, namely, C57BL/10 and mdx, exhibit differences in proliferative and myogenic abilities. The results suggest that the changes in mouse MSC behavior may be influenced by lack of dystrophin protein in mdx mouse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.