ArticleJournal of neuroinflammation2008
Persistent Borna Disease Virus (BDV) infection activates microglia prior to a detectable loss of granule cells in the hippocampus.
Article in Journal of neuroinflammation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Ex vivo study of neuroinvasive and neurotropic viruses: what is current and what is next.FEMS microbiology reviews · 2025Review
- Viral infections in etiology of mental disorders: a broad analysis of cytokine profile similarities - a narrative review.Frontiers in cellular and infection microbiology · 2024Review
- Brain-derived neurotrophic factor is down regulated after bovine alpha-herpesvirus 5 infection in both wild-type and TLR3/7/9 deficient mice.The Journal of veterinary medical science · 2021Article
- Interferon gamma protects neonatal neural stem/progenitor cells during measles virus infection of the brain.Journal of neuroinflammation · 2016Article
- Human but Not Laboratory Borna Disease Virus Inhibits Proliferation and Induces Apoptosis in Human Oligodendrocytes In Vitro.PloS one · 2013Article
- Microglia and monocyte-derived macrophages: functionally distinct populations that act in concert in CNS plasticity and repair.Frontiers in cellular neuroscience · 2013Article
- Borna disease virus infects human neural progenitor cells and impairs neurogenesis.Journal of virology · 2012Article
- Neuroinflammation resulting from covert brain invasion by common viruses - a potential role in local and global neurodegeneration.Medical hypotheses · 2010Article
- Chronic cortical and subcortical pathology with associated neurological deficits ensuing experimental herpes encephalitis.Brain pathology (Zurich, Switzerland) · 2010Article
- Inflammation in neurodegenerative diseases.Immunology · 2010Review
- Animal models of CNS viral disease: examples from borna disease virus models.Interdisciplinary perspectives on infectious diseases · 2010Article
- Failure to detect borna disease virus antibody and RNA from peripheral blood mononuclear cells of psychiatric patients.Psychiatry investigation · 2009Article
- Astrocytes play a key role in activation of microglia by persistent Borna disease virus infection.Journal of neuroinflammation · 2008Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Neonatal Borna Disease Virus (BDV) infection in rats leads to a neuronal loss in the cortex, hippocampus and cerebellum. Since BDV is a non-lytic infection in vitro, it has been suggested that activated microglia could contribute to neuronal damage. It is also conceivable that BDV-induced cell death triggers activation of microglia to remove cell debris. Although an overall temporal association between neuronal loss and microgliosis has been demonstrated in BDV-infected rats, it remains unclear if microgliosis precedes or results from neuronal damage. We investigated the timing of microglia activation and neuronal elimination in the dentate gyrus (DG) of the hippocampus. We found a significant increase in the number of ED1+ microglia cells as early as 10 days post infection (dpi) while a detectable loss of granule cells of the DG was not seen until 30 dpi. The data demonstrate for the first time that a non-lytic persistent virus infection of neurons activates microglia long before any measurable neuronal loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.