ArticleCell division2008
Insights from mouse models into human retinoblastoma.
Article in Cell division, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Who cites it
27 citing papers in PubMed.
- A temporal in vivo catalog of chromatin accessibility and expression profiles in pineoblastoma reveals a prevalent role for repressor elements.Genome research · 2023Article
- Article
- Second hit impels oncogenesis of retinoblastoma in patient-induced pluripotent stem cell-derived retinal organoids: direct evidence for Knudson's theory.PNAS nexus · 2022Article
- Review
- MYCN induces cell-specific tumorigenic growth in RB1-proficient human retinal organoid and chicken retina models of retinoblastoma.Oncogenesis · 2022Article
- Looking for In Vitro Models for Retinal Diseases.International journal of molecular sciences · 2021Review
- TargetingCancers · 2021Review
- Role of RB1 in human embryonic stem cell-derived retinal organoids.Developmental biology · 2020Article
- Article
- Transgenic Models in Retinoblastoma Research.Ocular oncology and pathology · 2015Review
- Generation of a Retinoblastoma (Rb)1-inducible dominant-negative (DN) mouse model.Frontiers in cellular neuroscience · 2015Article
- Regulation of mitotic cytoskeleton dynamics and cytokinesis by integrin-linked kinase in retinoblastoma cells.PloS one · 2014Article
- Animal models in retinoblastoma research.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society · 2013Article
- Optical coherence tomography for live phenotypic analysis of embryonic ocular structures in mouse models.Journal of biomedical optics · 2012Article
- Cooperation between Rb and Arf in suppressing mouse retinoblastoma.The Journal of clinical investigation · 2012Article
- The tumor suppressor gene retinoblastoma-1 is required for retinotectal development and visual function in zebrafish.PLoS genetics · 2012Article
- Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway.The Journal of experimental medicine · 2011Article
- Newly identified aspects of tumor suppression by RB.Disease models & mechanisms · 2011Review
- miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma.Genes & development · 2011Article
- miR than meets the eye.Genes & development · 2011Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Novel murine models of retinoblastoma based on Rb gene deletion in concert with inactivation of Rb family members have recently been developed. These new Rb knockout models of retinoblastoma provide excellent tools for pre-clinical studies and for the exploration of the genetics of tumorigenesis driven by RB inactivation. This review focuses on the developmental consequences of Rb deletion in the retina and the genetic interactions between Rb and the two other members of the pocket protein family, p107 (Rbl1) and p130 (Rbl2). There is increasing appreciation that homozygous RB mutations are insufficient for human retinoblastoma. Identifying and understanding secondary gene alterations that cooperate with RB inactivation in tumorigenesis may be facilitated by mouse models. Recent investigation of the p53 pathway in retinoblastoma, and evidence of spatial topology to early murine retinoblastoma are also discussed in this review.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.