ArticleBMC genomics2008
SNP discovery and molecular evolution in Anopheles gambiae, with special emphasis on innate immune system.
Article in BMC genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Transcriptional variation of sensory-related genes in natural populations of Aedes albopictus.BMC genomics · 2020Article
- Chromosomal inversions and ecotypic differentiation in Anopheles gambiae: the perspective from whole-genome sequencing.Molecular ecology · 2016Article
- Molecular evolution and population genetics of a Gram-negative binding protein gene in the malaria vector Anopheles gambiae (sensu lato).Parasites & vectors · 2016Article
- Genome-Wide Divergence in the West-African Malaria Vector Anopheles melas.G3 (Bethesda, Md.) · 2016Article
- Patterns of Genome-Wide Variation in Glossina fuscipes fuscipes Tsetse Flies from Uganda.G3 (Bethesda, Md.) · 2016Article
- Different evolutionary patterns of SNPs between domains and unassigned regions in human protein-coding sequences.Molecular genetics and genomics : MGG · 2016Article
- Genetic Structure of a Local Population of the Anopheles gambiae Complex in Burkina Faso.PloS one · 2016Article
- An Evolution-Based Screen for Genetic Differentiation between Anopheles Sister Taxa Enriches for Detection of Functional Immune Factors.PLoS pathogens · 2015Article
- Ancient DNA reveals that the genetic structure of the northern Han Chinese was shaped prior to 3,000 years ago.PloS one · 2015Article
- Population genetics of Anopheles coluzzii immune pathways and genes.G3 (Bethesda, Md.) · 2014Article
- No more non-model species: the promise of next generation sequencing for comparative immunology.Developmental and comparative immunology · 2014Review
- Positive selection drives accelerated evolution of mosquito salivary genes associated with blood-feeding.Insect molecular biology · 2014Article
- Diversity, differentiation, and linkage disequilibrium: prospects for association mapping in the malaria vector Anopheles arabiensis.G3 (Bethesda, Md.) · 2014Article
- No evidence for positive selection at two potential targets for malaria transmission-blocking vaccines in Anopheles gambiae s.s.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2013Article
- An analysis of two island groups as potential sites for trials of transgenic mosquitoes for malaria control.Evolutionary applications · 2013Article
- Role of cytochrome P450s in insecticide resistance: impact on the control of mosquito-borne diseases and use of insecticides on Earth.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Snpdat: easy and rapid annotation of results from de novo snp discovery projects for model and non-model organisms.BMC bioinformatics · 2013Article
- Evidence for population-specific positive selection on immune genes of Anopheles gambiae.G3 (Bethesda, Md.) · 2012Article
- Cloning and characterization of prophenoloxidase A3 (proPOA3) from Culex pipiens pallens.Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology · 2012Article
- Single-nucleotide polymorphisms for high-throughput genotyping of Anopheles arabiensis in East and southern Africa.Journal of medical entomology · 2012Article
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Authors and funding
8 authors.
Funding
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Abstract
backgroundAnopheles innate immunity affects Plasmodium development and is a potential target of innovative malaria control strategies. The extent and distribution of nucleotide diversity in immunity genes might provide insights into the evolutionary forces that condition pathogen-vector interactions. The discovery of polymorphisms is an essential step towards association studies of susceptibility to infection.
resultsWe sequenced coding fragments of 72 immune related genes in natural populations of Anopheles gambiae and of 37 randomly chosen genes to provide a background measure of genetic diversity across the genome. Mean nucleotide diversity (pi) was 0.0092 in the A. gambiae S form, 0.0076 in the M form and 0.0064 in A. arabiensis. Within each species, no statistically significant differences in mean nucleotide diversity were detected between immune related and non immune related genes. Strong purifying selection was detected in genes of both categories, presumably reflecting strong functional constraints.
conclusionOur results suggest similar patterns and rates of molecular evolution in immune and non-immune genes in A. gambiae. The 3,214 Single Nucleotide Polymorphisms (SNPs) that we identified are the first large set of Anopheles SNPs from fresh, field-collected material and are relevant markers for future phenotype-association studies.
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