Trial reportExperimental and clinical psychopharmacology2008
Bupropion improves attention but does not affect impulsive behavior in healthy young adults.
Trial report in Experimental and clinical psychopharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Does impulsivity change rate dependently following stimulant administration? A translational selective review and re-analysis.Psychopharmacology · 2016Pooled it
- Dopamine and Temporal Discounting: Revisiting Pharmacology and Individual Differences.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Trial
- Bidirectional modulation of reward-guided decision making by dopamine.Psychopharmacology · 2025Trial
- Safety and cognitive pharmacodynamics following dose escalations with 3-methylmethcathinone (3-MMC): a first in human, designer drug study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Trial
- The catecholamine precursor Tyrosine reduces autonomic arousal and decreases decision thresholds in reinforcement learning and temporal discounting.PLoS computational biology · 2022Trial
- Bupropion increases activation in nucleus accumbens during anticipation of monetary reward.Psychopharmacology · 2019Trial
- Effects of bupropion sustained release on task-related EEG alpha activity in smokers: Individual differences in drug response.Experimental and clinical psychopharmacology · 2017Trial
- Effects of acute dopamine precusor depletion on immediate reward selection bias and working memory depend on catechol-O-methyltransferase genotype.Journal of cognitive neuroscience · 2013Trial
- Effects of acute oral naltrexone on the subjective and physiological effects of oral D-amphetamine and smoked cocaine in cocaine abusers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Trial
- The effects of varenicline on attention and inhibitory control among treatment-seeking smokers.Psychopharmacology · 2012Trial
- Discounting of probabilistic rewards is associated with gambling abstinence in treatment-seeking pathological gamblers.Journal of abnormal psychology · 2012Trial
- Effects of varenicline and bupropion on cognitive processes among nicotine-deprived smokers.Experimental and clinical psychopharmacology · 2012Trial
- The dopamine augmenter L-DOPA does not affect positive mood in healthy human volunteers.PloS one · 2012Trial
- Galantamine improves sustained attention in chronic cocaine users.Experimental and clinical psychopharmacology · 2011Trial
- Effect of D-amphetamine on inhibition and motor planning as a function of baseline performance.Psychopharmacology · 2010Trial
- Catechol-O-methyltransferase val158met genotype modulates sustained attention in both the drug-free state and in response to amphetamine.Psychiatric genetics · 2010Trial
- The prescription opioid, oxycodone, does not alter behavioral measures of impulsivity in healthy volunteers.Pharmacology, biochemistry, and behavior · 2009Trial
- Stimulant treatment reduces lapses in attention among children with ADHD: the effects of methylphenidate on intra-individual response time distributions.Journal of abnormal child psychology · 2009Trial
- Review: Suicide and its relationship to aggression and impulsivity.Cognitive, affective & behavioral neuroscience · 2025Review
- Cross-species translational paradigms for assessing positive valence system as defined by the RDoC matrix.Journal of neurochemistry · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Bupropion is an effective abstinence aid for cessation of smoking and possibly other drug use as well. There is evidence that bupropion improves attention and impulse control in certain patient populations, and improvements in these processes could mediate its efficacy as an abstinence aid. In the present study, we tested the effects of acute bupropion on measures of attention and impulsivity in healthy adults with d-amphetamine included as a positive control. Twenty-two nonsmokers (11 women) and 11 smokers (4 women) completed four 4-hr sessions where they received placebo, bupropion (150 or 300 mg), or d-amphetamine (20 mg) in capsules. Ninety minutes after capsule administration, participants were tested on attention with a simple reaction time task (SRT) and on impulsivity with the stop task, a delay and probability discounting task (DPD), and the balloon analogue risk task (BART). Participants also completed mood questionnaires during sessions. Bupropion (150 mg) decreased lapses in attention on the SRT, but did not affect performance on the stop task, DPD, or BART. Amphetamine decreased lapses in attention and speeded sensory motor processing time on the SRT but did not significantly affect responding on the stop task or DPD. On the BART, d-amphetamine tended to decrease risk taking in men but increased risk taking in women. Bupropion (300 mg) and d-amphetamine increased ratings of arousal. These results suggest that bupropion improves attention without affecting impulsive behavior in healthy adults. Improvements in attention may contribute to the effectiveness of bupropion as a pharmacotherapy for smoking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.