Evidence map›Paper›PMID 18489002›Full record

ReviewDevelopmental dynamics : an official publication of the American Association of Anatomists2008

Intraflagellar transport and the sensory outer segment of vertebrate photoreceptors.

Christine Insinna, Joseph C Besharse

Open access · greenAbstract readReview
In one paragraph

Review in Developmental dynamics : an official publication of the American Association of Anatomists, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 187 citations in OpenAlex.

  1. Primary cilia: sensors of biliary homeostasis and disease.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  2. Article
  3. Review
  4. Complement Factor H and itsbioRxiv : the preprint server for biology · 2025
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
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  13. Article
  14. Clinical and Molecular Aspects of C2orf71/PCARE in Retinal Diseases.International journal of molecular sciences · 2023
    Review
  15. Article
  16. Shedding of ciliary vesicles at a glance.Journal of cell science · 2022
    Article
  17. Review
  18. Article
  19. Biochemistry and physiology of zebrafish photoreceptors.Pflugers Archiv : European journal of physiology · 2021
    Review
  20. Structure and dynamics of photoreceptor sensory cilia.Pflugers Archiv : European journal of physiology · 2021
    Review

57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christine InsinnaDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226-0509, USA.
Joseph C Besharse
Medical College of Wisconsin · US

Funding

MORPHOLOGY MODULEP30EY001931 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI LINK, BRIAN A · 1985 to 2016
$9.8M
VISUAL CELL-PIGMENT CELL INTERFACE AND DISC TURNOVERR01EY003222 · NEI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI BESHARSE, JOSEPH C · 1985 to 2016
$5.0M
Rresearch Training Program in Vision ScienceT32EY014537 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI Elena V Semina · 2002 to 2026
$4.2M
STUDIES ON DISK RENEWAL IN RETINAL VISUAL CELLSR01EY002414 · NEI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI BESHARSE, JOSEPH C · 1985 to 2008
$3.2M
LEICA TCS SPII SPECTRAL CONFOCAL MICROSCOPES10RR015679 · NCRR · MEDICAL COLLEGE OF WISCONSIN · PI BESHARSE, JOSEPH C · 2001 to 2001
$351k
NCRR NIH HHS S10 RR015679NEI NIH HHS EY03222NEI NIH HHS P30 EY001931NEI NIH HHS R01 EY002414NEI NIH HHS R01 EY003222NEI NIH HHS T32 EY014537NEI NIH HHS T32-EY014537
6 · The paper itself

Abstract

Analysis of the other segments of rod and cone photoreceptors in vertebrates has provided a rich molecular understanding of how light absorbed by a visual pigment can result in changes in membrane polarity that regulate neurotransmitter release. These events are carried out by a large group of phototransduction proteins that are enriched in the outer segment. However, the mechanisms by which phototransduction proteins are sequestered in the outer segment are not well defined. Insight into those mechanisms has recently emerged from the findings that outer segments arise from the plasma membrane of a sensory cilium, and that intraflagellar transport (IFT), which is necessary for assembly of many types of cilia and flagella, plays a crucial role. Here we review the general features of outer segment assembly that may be common to most sensory cilia as well those that may be unique to the outer segment. Those features illustrate how further analysis of photoreceptor IFT may provide insight into both IFT cargo and the role of alternative IFT kinesins.

Indexed as

AnimalsBiological TransportCiliaFlagellaHumansPhotoreceptor Cells, VertebrateVertebratesVision, Ocular

Identifiers

PMID18489002
PMCPMC2692564
OpenAlexW2083026402

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.