ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2008
What's left in asymmetry?
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Programmed cell death along the midline axis patterns ipsilaterality in gastrulation.Science (New York, N.Y.) · 2020Article
- From cytoskeletal dynamics to organ asymmetry: a nonlinear, regulative pathway underlies left-right patterning.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- The chicken left right organizer has nonmotile cilia which are lost in a stage-dependent manner in the talpid(3) ciliopathy.Genesis (New York, N.Y. : 2000) · 2014Article
- Left-right patterning in Xenopus conjoined twin embryos requires serotonin signaling and gap junctions.The International journal of developmental biology · 2014Article
- It's never too early to get it Right: A conserved role for the cytoskeleton in left-right asymmetry.Communicative & integrative biology · 2013Article
- Inversion of left-right asymmetry alters performance ofAnimal behaviour · 2013Article
- Polarity proteins are required for left-right axis orientation and twin-twin instruction.Genesis (New York, N.Y. : 2000) · 2012Article
- Left-right symmetry breaking in tissue morphogenesis via cytoskeletal mechanics.Circulation research · 2012Article
- Evidence for avian cell autonomous sex identity (CASI) and implications for the sex-determination process?Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Review
- SHROOM3 is a novel candidate for heterotaxy identified by whole exome sequencing.Genome biology · 2011Article
- Far from solved: a perspective on what we know about early mechanisms of left-right asymmetry.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Review
- The ATP-sensitive K(+)-channel (K(ATP)) controls early left-right patterning in Xenopus and chick embryos.Developmental biology · 2010Article
- Consistent left-right asymmetry cannot be established by late organizers in Xenopus unless the late organizer is a conjoined twin.Development (Cambridge, England) · 2010Article
- Left-right asymmetry in the chick embryo requires core planar cell polarity protein Vangl2.Genesis (New York, N.Y. : 2000) · 2009Article
- Perspectives and open problems in the early phases of left-right patterning.Seminars in cell & developmental biology · 2009Review
- Is left-right asymmetry a form of planar cell polarity?Development (Cambridge, England) · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Left-right patterning is a fascinating problem of morphogenesis, linking evolutionary and cellular signaling mechanisms across many levels of organization. In the past 15 years, enormous progress has been made in elucidating the molecular details of this process in embryos of several model species. While many outside the field seem to believe that the fundamental aspects of this pathway are now solved, workers on asymmetry are faced with considerable uncertainties over the details of specific mechanisms, a lack of conceptual unity of mechanisms across phyla, and important questions that are not being pursued in any of the popular model systems. Here, we suggest that data from clinical syndromes, cryptic asymmetries, and bilateral gynandromorphs, while not figuring prominently in the mainstream work on LR asymmetry, point to crucial and fundamental gaps of knowledge about asymmetry. We identify 12 big questions that provide exciting opportunities for fundamental new advances in this field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.