ArticleThe Journal of cell biology1991
Cortical alveoli of Paramecium: a vast submembranous calcium storage compartment.
Article in The Journal of cell biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 133 citations in OpenAlex.
- Calcium Ions as Conjugation-Specific Regulators inMicroorganisms · 2026Article
- Calmodulin inMicroorganisms · 2022Review
- Anterior-posterior pattern formation in ciliates.The Journal of eukaryotic microbiology · 2022Review
- Identifying the Target of an Antiparasitic Compound inACS chemical biology · 2020Article
- Knockdown of Dinoflagellate Cellulose SynthaseFrontiers in microbiology · 2019Article
- Article
- An evolutionary balance: conservation vs innovation in ciliate membrane trafficking.Traffic (Copenhagen, Denmark) · 2017Review
- Using a Genetically Encoded Sensor to Identify Inhibitors of Toxoplasma gondii Ca2+ Signaling.The Journal of biological chemistry · 2016Article
- Tetrahymena thermophila: a divergent perspective on membrane traffic.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2014Review
- Intracellular calcium channels in protozoa.European journal of pharmacology · 2014Review
- Cryptic organelle homology in apicomplexan parasites: insights from evolutionary cell biology.Current opinion in microbiology · 2013Article
- Evolution of apicomplexan secretory organelles.International journal for parasitology · 2012Review
- Cytoskeleton assembly in Toxoplasma gondii cell division.International review of cell and molecular biology · 2012Review
- Calcium-release channels in paramecium. Genomic expansion, differential positioning and partial transcriptional elimination.PloS one · 2011Article
- A novel family of Toxoplasma IMC proteins displays a hierarchical organization and functions in coordinating parasite division.PLoS pathogens · 2010Article
- Novel types of Ca2+ release channels participate in the secretory cycle of Paramecium cells.Molecular and cellular biology · 2009Article
- Review
- Distinct localization of a beta-tubulin epitope in the Tetrahymena thermophila and Paramecium caudatum cortex.Protoplasma · 2005Article
- Proposed function of the accumulation of plasma membrane-type Ca2+-ATPase mRNA in resting cysts of the ciliate Sterkiella histriomuscorum.Eukaryotic cell · 2005Article
- Functional role of epsilon-tubulin in the assembly of the centriolar microtubule scaffold.The Journal of cell biology · 2002Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plasma membrane of Paramecium is underlain by a continuous layer of membrane vesicles known as cortical alveoli, whose function was unknown but whose organization had suggested some resemblance with muscle sarcoplasmic reticulum. The occurrence of antimonate precipitates within the alveoli first indicated to us that they may indeed correspond to a vast calcium storage site. To analyze the possible involvement of this compartment in calcium sequestration more directly, we have developed a new fractionation method, involving a Percoll gradient, that allows rapid purification of the surface layer (cortex) of Paramecium in good yield and purity and in which the alveoli retain their in vivo topological orientation. This fraction pumped calcium very actively in a closed membrane compartment, with strict dependence on ATP and Mg2+. The pumping activity was affected by anti-calmodulin drugs but no Triton-soluble calmodulin binding protein could be identified, using gel overlay procedures. The high affinity of the pump for calcium (Km = 0.5 microM) suggests that it plays an important role in the normal physiological environment of the cytosol. This may be related to at least three calcium-regulated processes that take place in the immediate vicinity of alveoli: trichocyst exocytosis, ciliary beating and cytoskeletal elements dynamics during division.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.