ArticleInternational journal of nanomedicine2008
Association between Randall's plaque and calcifying nanoparticles.
Article in International journal of nanomedicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Role of ROS-Induced NLRP3 Inflammasome Activation in the Formation of Calcium Oxalate Nephrolithiasis.Frontiers in immunology · 2022Pooled it
- Clinical implications of calcifying nanoparticles in dental diseases: a critical review.International journal of nanomedicine · 2014Pooled it
- Cell Calcification Models and Their Implications for Medicine and Biomaterial Research.Advanced healthcare materials · 2026Review
- Mechanism of influence of calcified nanoparticles in the development of calcified diseases (Review).Biomedical reports · 2025Review
- Predictive value of Controlling Nutritional Status score and Prognostic Nutritional Index for systemic inflammatory response syndrome/sepsis after percutaneous nephrolithotomy.International urology and nephrology · 2023Article
- Human kidney stones: a natural record of universal biomineralization.Nature reviews. Urology · 2021Review
- [Current concepts on the pathogenesis of urinary stones].Der Urologe. Ausg. A · 2019Review
- Calcifying nanoparticles induce cytotoxicity mediated by ROS-JNK signaling pathways.Urolithiasis · 2019Article
- A continuum of mineralization from human renal pyramid to stones on stems.Acta biomaterialia · 2018Article
- Kidney stone formers have more renal parenchymal crystals than non-stone formers, particularly in the papilla region.BMC urology · 2018Article
- Apoptosis-mediated endothelial toxicity but not direct calcification or functional changes in anti-calcification proteins defines pathogenic effects of calcium phosphate bions.Scientific reports · 2016Article
- Nanoparticle Tracking Analysis for the Enumeration and Characterization of Mineralo-Organic Nanoparticles in Feline Urine.PloS one · 2016Article
- Morphological and chemical study of pathological deposits in human aortic and mitral valve stenosis: a biomineralogical contribution.Pathology research international · 2015Article
- Vascular theory of the formation of Randall plaques.Urolithiasis · 2015Review
- Papillary calcifications: a new prognostic factor in idiopathic calcium oxalate urolithiasis.Urolithiasis · 2013Article
- The role of calcium phosphate in the development of Randall's plaques.Urolithiasis · 2013Review
- Bions: a family of biomimetic mineralo-organic complexes derived from biological fluids.PloS one · 2013Article
- Randall plaque versus renal stone?Translational andrology and urology · 2012Article
- Association between calcifying nanoparticles and placental calcification.International journal of nanomedicine · 2012Article
- The role of calcifying nanoparticles in biology and medicine.International journal of nanomedicine · 2012Review
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9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesRandall initially described calcified subepithelial papillary plaques, which he hypothesized as nidi for urinary calculi. The discovery of calcifying nanoparticles (CNP), also referred to as nanobacteria, in calcified soft tissues has raised another hypothesis about their possible involvement in urinary stone formation. This research is the first attempt to investigate the potential association of these two hypotheses.
methodsWe collected renal papilla and blood samples from 17 human patients who had undergone laparoscopic nephrectomy. Immunohistochemical staining (IHS) was applied using monoclonal antibody (mAb) against CNP. Homogenized papillary tissues and serum samples were cultured for CNP. Scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS) were performed on papillary samples. Serum samples were tested for CNP antigen and antibody with enzyme-linked immunosorbent assay (ELISA).
resultsRandall's plaques (RP) were visible on gross inspection in 11 out of 17 samples. IHS was positive for CNP antigen in 8 of the visually positive samples, but in only 1 of the remaining samples. SEM revealed spherical apatite-formations in 14 samples confirmed by EDS analysis. In cultures, all serum samples and 13 tissue homogenates grew CNP. In ELISA, 14 samples were positive for CNP-antigen and 11 samples were positive for CNP-antibody.
conclusionThere was evidence of a link between detection of CNP and presence of RP. Although causality was not demonstrated, these results suggest that further studies with negative control samples should be made to explore the etiology of RP formation, thus leading to a better understanding of the pathogenesis of stone formation.
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