ArticleInternational journal of nanomedicine2008
Cytotoxicity and reactive oxygen species generation from aggregated carbon and carbonaceous nanoparticulate materials.
Article in International journal of nanomedicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 99 citations in OpenAlex.
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- Dimeric 3,5-Bis(benzylidene)-4-piperidones: Tumor-Selective Cytotoxicity and Structure-Activity Relationships.Medicines (Basel, Switzerland) · 2024Article
- High rise in carbonaceous aerosols under very low anthropogenic emissions over eastern Himalaya, India: Impact of lockdown for COVID-19 outbreak.Atmospheric environment (Oxford, England : 1994) · 2021Article
- Cyanographene and Graphene Acid: Emerging Derivatives Enabling High-Yield and Selective Functionalization of Graphene.ACS nano · 2017Article
- Evaluation of Complex Toxicity of Canbon Nanotubes and Sodium Pentachlorophenol Based on Earthworm Coelomocytes Test.PloS one · 2017Article
- Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema.eLife · 2015Article
- Polycyclic aromatic hydrocarbons and childhood asthma.European journal of epidemiology · 2015Review
- Oxidative stress and antibacterial properties of a graphene oxide-cystamine nanohybrid.International journal of nanomedicine · 2015Article
- Physicochemical and toxicological characteristics of urban aerosols during a recent Indonesian biomass burning episode.Environmental science and pollution research international · 2013Article
- Stress response and tolerance of Zea mays to CeO2 nanoparticles: cross talk among H2O2, heat shock protein, and lipid peroxidation.ACS nano · 2012Article
- Comparative microstructures and cytotoxicity assays for ballistic aerosols composed of micrometals and nanometals: respiratory health implications.International journal of nanomedicine · 2011Article
- Microstructures and nanostructures for environmental carbon nanotubes and nanoparticulate soots.International journal of environmental research and public health · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have investigated the cytotoxicity and reactive oxygen species (ROS) generation for indoor and outdoor soots: candle, wood, diesel, tire, and natural gas burner soots--along with surrogate black carbon, various multiwall carbon nanotube aggregate materials, TiO2 (anatase) and chrysotile asbestos as reference materials. All soots were observed utilizing TEM and FESEM to be composed of aggregated, primary spherules (20-80 nm diameter) forming complex, branched fractal structures. These spherules were composed of intercalated, turbostratic arrangements of curved graphene fragments with varying concentrations ofpolycyclic aromatic hydrocarbon (PAH) isomers. In vitro cultures with an immortalized human lung epithelial carcinoma cell line (A549) treated with these materials showed decreased cell viability and variations in ROS production, with no correlations to PAH content. The data demonstrate that soots are cytotoxic and that cytotoxicity is not related to PAH content but is related to ROS generation, suggesting that soot induces cellular oxidative stress and that cell viability assays can be indicators of ROS production.
Indexed as
Identifiers
18488419PMC2526363W2060018286What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.