ReviewInternational journal of nanomedicine2008
Nano-vectors for efficient liver specific gene transfer.
Review in International journal of nanomedicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 66 citations in OpenAlex.
- Progress, evolving therapeutic/diagnostic approaches, and challenges in the management of hepatitis C virus infections.Archives of virology · 2022Review
- Article
- Efficient drug and gene delivery to liver fibrosis: rationale, recent advances, and perspectives.Acta pharmaceutica Sinica. B · 2020Review
- Gene delivery into hepatic cells with ternary complexes of plasmid DNA, cationic liposomes and apolipoprotein E-derived peptide.Experimental and therapeutic medicine · 2019Article
- The effects of multifunctional MiR-122-loaded graphene-gold composites on drug-resistant liver cancer.Journal of nanobiotechnology · 2015Article
- Lactoferrin-modified PEGylated liposomes loaded with doxorubicin for targeting delivery to hepatocellular carcinoma.International journal of nanomedicine · 2015Article
- Glucose-containing diblock polycations exhibit molecular weight, charge, and cell-type dependence for pDNA delivery.Biomacromolecules · 2014Article
- Mouse models for liver cancer.Molecular oncology · 2013Review
- Improvement of hydrodynamics-based gene transfer of nonviral DNA targeted to murine hepatocytes.BioMed research international · 2013Article
- Efficient hepatic delivery of drugs: novel strategies and their significance.BioMed research international · 2013Review
- Comparison of two kinds of nanomedicine for targeted gene therapy: premodified or postmodified gene delivery systems.International journal of nanomedicine · 2012Article
- Optimizing Druggability through Liposomal Formulations: New Approaches to an Old Concept.ISRN pharmaceutics · 2012Article
- Article
- Triolein-based polycation lipid nanocarrier for efficient gene delivery: characteristics and mechanism.International journal of nanomedicine · 2011Article
- A study on the preparation and characterization of plasmid DNA and drug-containing magnetic nanoliposomes for the treatment of tumors.International journal of nanomedicine · 2011Article
- Gene therapy for liver regeneration: experimental studies and prospects for clinical trials.World journal of gastroenterology · 2010Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent progress in nanotechnology has triggered the site specific drug/gene delivery research and gained wide acknowledgment in contemporary DNA therapeutics. Amongst various organs, liver plays a crucial role in various body functions and in addition, the site is a primary location of metastatic tumor growth. In past few years, a plethora of nano-vectors have been developed and investigated to target liver associated cells through receptor mediated endocytosis. This emerging paradigm in cellular drug/gene delivery provides promising approach to eradicate genetic as well as acquired diseases affecting the liver. The present review provides a comprehensive overview of potential of various delivery systems, viz., lipoplexes, liposomes, polyplexes, nanoparticles and so forth to selectively relocate foreign therapeutic DNA into liver specific cell type via the receptor mediated endocytosis. Various receptors like asialoglycoprotein receptors (ASGP-R) provide unique opportunity to target liver parenchymal cells. The results obtained so far reveal tremendous promise and offer enormous options to develop novel DNA-based pharmaceuticals for liver disorders in near future.
Indexed as
Identifiers
18488414PMC2526359W2151666924What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.