ArticleImmunogenetics2008
Two canine CD1a proteins are differentially expressed in skin.
Article in Immunogenetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- A canine macrophage cell line that can be polarized provides a model for canine macrophage differentiation.Scientific reports · 2026Article
- CD1-restricted T cells: are unconventional allies the key to future TB vaccines?Frontiers in immunology · 2025Review
- Role of NK-Like CD8Infection and immunity · 2022Article
- A TCR β-Chain Motif Biases toward Recognition of Human CD1 Proteins.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Mammalian CD1 and MR1 genes.Immunogenetics · 2016Review
- Refinement of the canine CD1 locus topology and investigation of antibody binding to recombinant canine CD1 isoforms.Immunogenetics · 2016Article
- Lipid and small-molecule display by CD1 and MR1.Nature reviews. Immunology · 2015Review
- CD1 and mycobacterial lipids activate human T cells.Immunological reviews · 2015Review
- Expression patterns of bovine CD1 in vivo and assessment of the specificities of the anti-bovine CD1 antibodies.PloS one · 2015Article
- The equine CD1 gene family is the largest and most diverse yet identified.Immunogenetics · 2014Article
- Molecular basis of lipid antigen presentation by CD1d and recognition by natural killer T cells.Immunological reviews · 2012Review
- Crystal structures of bovine CD1d reveal altered αGalCer presentation and a restricted A' pocket unable to bind long-chain glycolipids.PloS one · 2012Article
- CD1a-autoreactive T cells are a normal component of the human αβ T cell repertoire.Nature immunology · 2010Article
- Crystal structure of bovine CD1b3 with endogenously bound ligands.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Article
- Comparative analysis of canine monocyte- and bone-marrow-derived dendritic cells.Veterinary researchArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipid antigens are presented to T cells by the CD1 family of proteins. In this study, we characterize the complete dog (Canis familiaris) CD1 locus, which is located on chromosome 38. The canine locus contains eight CD1A genes (canCD1A), of which five are pseudogenes, one canCD1B, one canCD1C, one canCD1D, and one canCD1E gene. In vivo expression of canine CD1 proteins was shown for canCD1a6, canCD1a8, and canCD1b, using a panel of anti-CD1 monoclonal antibodies (mAbs). CanCD1a6 and canCD1a8 are recognized by two distinct mAbs. Furthermore, we show differential transcription of the three canCD1A genes in canine tissues. In canine skin, the transcription level of canCD1A8 was higher than that of canCD1A6, and no transcription of canCD1A2 was detected. Based on protein modeling and protein sequence alignment, we predict that both canine CD1a proteins can bind different glycolipids in their groove. Besides differences in ectodomain structure, we observed the unique presence of three types of cytoplasmic tails encoded by canCD1A genes. cDNA sequencing and expressed sequence tag sequences confirmed the existence of a short, human CD1a-like cytoplasmic tail of four amino acids, of an intermediate length form of 15 amino acids, and of a long form of 31 amino acids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.