ArticleEpilepsy currents
Seizures beget seizures in temporal lobe epilepsies: the boomerang effects of newly formed aberrant kainatergic synapses.
Article in Epilepsy currents. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 62 citations in OpenAlex.
- Expansion of epileptogenic networks via neuroplasticity in neural mass models.PLoS computational biology · 2024Article
- Regulation of specific abnormal calcium signals in the hippocampal CA1 and primary cortex M1 alleviates the progression of temporal lobe epilepsy.Neural regeneration research · 2024Article
- The Role of Glutamate Receptors in Epilepsy.Biomedicines · 2023Review
- Altered Cerebro-Cerebellar Effective Connectivity in New-Onset Juvenile Myoclonic Epilepsy.Brain sciences · 2022Article
- Light, Kindling, Action! Brain-Wide Circuit Changes After Optogenetic Hippocampal Kindling Revealed by Functional Magnetic Resonance Imaging.Epilepsy currents · 2022Article
- Disruption of Cerebellar-Cerebral Functional Connectivity in Temporal Lobe Epilepsy and the Connection to Language and Cognitive Functions.Frontiers in neuroscience · 2022Article
- Distinct limbic connectivity in left and right benign mesial temporal lobe epilepsy: Evidence from a resting state functional MRI study.Frontiers in neurology · 2022Article
- Hubs disruption in mesial temporal lobe epilepsy. A resting-state fMRI study on a language-and-memory network.Human brain mapping · 2020Article
- Ube3a reinstatement mitigates epileptogenesis in Angelman syndrome model mice.The Journal of clinical investigation · 2019Article
- Novel Optogenetic Approaches in Epilepsy Research.Frontiers in neuroscience · 2019Review
- Neurobiological Correlates of Alpha-Tocopherol Antiepileptogenic Effects and MicroRNA Expression Modulation in a Rat Model of Kainate-Induced Seizures.Molecular neurobiology · 2018Article
- The Widespread Network Effects of Focal Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Kainate Receptors: Role in Epilepsy.Frontiers in molecular neuroscience · 2018Review
- Neuron subset-specific Pten deletion induces abnormal skeletal activity in mice.Experimental neurology · 2017Article
- Network Analysis on Predicting Mean Diffusivity Change at Group Level in Temporal Lobe Epilepsy.Brain connectivity · 2016Article
- Role ofBiochemistry and biophysics reports · 2015Article
- The kainic acid model of temporal lobe epilepsy.Neuroscience and biobehavioral reviews · 2013Review
- Déjà vu phenomenon-related EEG pattern. Case report.Epilepsy & behavior case reports · 2013Article
- Synaptic kainate receptors in interplay with INaP shift the sparse firing of dentate granule cells to a sustained rhythmic mode in temporal lobe epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Primary and secondary mechanisms of epileptogenesis in the temporal lobe: there is a before and an after.Epilepsy currents · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Do temporal lobe epilepsy (TLE) seizures in adults promote further seizures? Clinical and experimental data suggest that new synapses are formed after an initial episode of status epilepticus, however their contribution to the transformation of a naive network to an epileptogenic one has been debated. Recent experimental data show that newly formed aberrant excitatory synapses on the granule cells of the fascia dentate operate by means of kainate receptor-operated signals that are not present on naive granule cells. Therefore, genuine epileptic networks rely on signaling cascades that differentiate them from naive networks. Recurrent limbic seizures generated by the activation of kainate receptors and synapses in naive animals lead to the formation of novel synapses that facilitate the emergence of further seizures. This negative, vicious cycle illustrates the central role of reactive plasticity in neurological disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.