ArticleProceedings of the National Academy of Sciences of the United States of America2008
Acidity enhances the formation of a persistent ozonide at aqueous ascorbate/ozone gas interfaces.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Spontaneous formation of reactive redox radical species at the interface of gas diffusion electrode.Nature communications · 2024Article
- Stability of Terpenoid-Derived Secondary Ozonides in Aqueous Organic Media.The journal of physical chemistry. A · 2022Article
- Molecular reactions at aqueous interfaces.Nature reviews. Chemistry · 2020Review
- Iodide Accelerates the Processing of Biogenic Monoterpene Emissions on Marine Aerosols.ACS omega · 2019Article
- OH-Radical Oxidation of Lung Surfactant Protein B on Aqueous Surfaces.Mass spectrometry (Tokyo, Japan) · 2018Article
- Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants.Environmental science & technology · 2017Article
- Chemical exposure-response relationship between air pollutants and reactive oxygen species in the human respiratory tract.Scientific reports · 2016Article
- Going beyond electrospray: mass spectrometric studies of chemical reactions in and on liquids.Chemical science · 2016Article
- Nanoscale interfacial gradients formed by the reactive uptake of OH radicals onto viscous aerosol surfaces.Chemical science · 2015Article
- Fenton chemistry at aqueous interfaces.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- A microfluidic-based bubble generation platform enables analysis of physical property change in phospholipid surfactant layers by interfacial ozone reaction.Lab on a chip · 2012Article
- Brønsted basicity of the air-water interface.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Anions dramatically enhance proton transfer through aqueous interfaces.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Gas uptake and chemical aging of semisolid organic aerosol particles.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Time resolved studies of interfacial reactions of ozone with pulmonary phospholipid surfactants using field induced droplet ionization mass spectrometry.The journal of physical chemistry. B · 2010Article
- Interfacial reactions of ozone with surfactant protein B in a model lung surfactant system.Journal of the American Chemical Society · 2010Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The pulmonary epithelium, like most aerial biosurfaces, is naturally protected against atmospheric ozone (O(3)) by fluid films that contain ascorbic acid (AH(2)) and related scavengers. This mechanism of protection will fail, however, if specific copollutants redirect AH(2) and O(3)(g) to produce species that can transduce oxidative damage to underlying tissues. Here, the possibility that the synergistic adverse health effects of atmospheric O(3)(g) and acidic particulate matter revealed by epidemiological studies could be mediated by hitherto unidentified species is investigated by electrospray mass spectrometry of aqueous AH(2) droplets exposed to O(3)(g). The products of AH(2) ozonolysis at the relevant air-water interface shift from the innocuous dehydroascorbic acid at biological pH to a C(4)-hydroxy acid plus a previously unreported ascorbate ozonide (m/z = 223) below pH approximately 5. The structure of this ozonide is confirmed by tandem mass spectrometry and its mechanism of formation delineated by kinetic studies. Present results imply enhanced production of a persistent ozonide in airway-lining fluids acidified by preexisting pathologies or inhaled particulate matter. Ozonides are known to generate cytotoxic free radicals in vivo and can, therefore, transduce oxidative damage.
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