ArticleDiabetes2008
Impact of oxidative stress and peroxisome proliferator-activated receptor gamma coactivator-1alpha in hepatic insulin resistance.
Article in Diabetes, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 90 citations in OpenAlex.
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- An upstream open reading frame (5'-uORF) links oxidative stress to translational control of ALCAT1 through phosphorylation of eIF2α.Free radical biology & medicine · 2024Article
- Characterization of dipyridamole as a novel ferroptosis inhibitor and its therapeutic potential in acute respiratory distress syndrome management.Theranostics · 2024Article
- Nano-titanium dioxide inhalation exposure during gestation drives redox dysregulation and vascular dysfunction across generations.Particle and fibre toxicology · 2022Article
- Apigenin Isolated fromMolecules (Basel, Switzerland) · 2022Article
- DPP4 Activity, Hyperinsulinemia, and Atherosclerosis.The Journal of clinical endocrinology and metabolism · 2021Review
- Non-Esterified Fatty Acids and Risks of Frailty, Disability, and Mobility Limitation in Older Adults: The Cardiovascular Health Study.Journal of the American Geriatrics Society · 2020Article
- Western diet induces severe nonalcoholic steatohepatitis, ductular reaction, and hepatic fibrosis in liver CGI-58 knockout mice.Scientific reports · 2020Article
- Effect of Hepatitis Viruses on the Nrf2/Keap1-Signaling Pathway and Its Impact on Viral Replication and Pathogenesis.International journal of molecular sciences · 2019Review
- Oxidative Imbalance and Kidney Damage in Cafeteria Diet-Induced Rat Model of Metabolic Syndrome: Effect of Bergamot Polyphenolic Fraction.Antioxidants (Basel, Switzerland) · 2019Article
- Prognostic Impact of Fasting Plasma Glucose on Mortality and Re-Hospitalization in Patients with Acute Heart Failure.Chinese medical journal · 2018Article
- Curcumin supplementation mitigates NASH development and progression in female Wistar rats.Physiological reports · 2018Article
- Characteristics of hepatic insulin-sensitive nonalcoholic fatty liver disease.Hepatology communications · 2017Article
- The Janus Head of Oxidative Stress in Metabolic Diseases and During Physical Exercise.Current diabetes reports · 2017Review
- Effects of alcohol abstinence on glucose metabolism in Japanese men with elevated fasting glucose: A pilot study.Scientific reports · 2017Article
- HCV and Oxidative Stress: Implications for HCV Life Cycle and HCV-Associated Pathogenesis.Oxidative medicine and cellular longevity · 2016Review
- Article
- A small amount of dietary carbohydrate can promote the HFD-induced insulin resistance to a maximal level.PloS one · 2014Article
- Neuroendocrine and metabolic components of dopamine agonist amelioration of metabolic syndrome in SHR rats.Diabetology & metabolic syndrome · 2014Article
- Nonalcoholic Fatty liver disease: pathogenesis and therapeutics from a mitochondria-centric perspective.Oxidative medicine and cellular longevity · 2014Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveRecent studies identified accumulation of reactive oxygen species (ROS) as a common pathway causing insulin resistance. However, whether and how the reduction of ROS levels improves insulin resistance remains to be elucidated. The present study was designed to define this mechanism. RESEARCH DESIGN AND
methodsWe investigated the effect of overexpression of superoxide dismutase (SOD)1 in liver of obese diabetic model (db/db) mice by adenoviral injection.
resultsdb/db mice had high ROS levels in liver. Overexpression of SOD1 in liver of db/db mice reduced hepatic ROS and blood glucose level. These changes were accompanied by improvement in insulin resistance and reduction of hepatic gene expression of phosphoenol-pyruvate carboxykinase and peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha), which is the main regulator of gluconeogenic genes. The inhibition of hepatic insulin resistance was accompanied by attenuation of phosphorylation of cAMP-responsive element-binding protein (CREB), which is a main regulator of PGC-1alpha expression, and attenuation of Jun NH(2)-terminal kinase (JNK) phosphorylation. Simultaneously, overexpression of SOD1 in db/db mice enhanced the inactivation of forkhead box class O1, another regulator of PGC-1alpha expression, without the changes of insulin-induced Akt phosphorylation in liver. In hepatocyte cell lines, ROS induced phosphorylation of JNK and CREB, and the latter, together with PGC-1alpha expression, was inhibited by a JNK inhibitor.
conclusionsOur results indicate that the reduction of ROS is a potential therapeutic target of liver insulin resistance, at least partly by the reduced expression of PGC-1alpha.
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