ArticleJournal of bacteriology2008
Impact of individual mutations on increased fitness in adaptively evolved strains of Escherichia coli.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 52 citations in OpenAlex.
- Plug-and-play evolution of the Klebsiella pneumoniae capsule locus enables serotype exchange across genetic backgrounds.PLoS biology · 2026Article
- Compensatory evolution of chromosomes and plasmids counteracts the plasmid fitness cost.Ecology and evolution · 2024Article
- DNA Breaks-Mediated Fitness Cost Reveals RNase HI as a New Target for Selectively Eliminating Antibiotic-Resistant Bacteria.Molecular biology and evolution · 2021Article
- Experimental Evolution of Anticipatory Regulation inFrontiers in microbiology · 2021Article
- Metabolic Modeling of Streptococcus mutans Reveals Complex Nutrient Requirements of an Oral Pathogen.mSystems · 2019Article
- Increased biofilm formation due to high-temperature adaptation in marine Roseobacter.Nature microbiology · 2018Article
- Parallel genetic adaptation across environments differing in mode of growth or resource availability.Evolution letters · 2018Article
- Article
- Sexual recombination and increased mutation rate expedite evolution of Escherichia coli in varied fitness landscapes.Nature communications · 2017Article
- The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is shaped by strong epistatic interactions.Nature communications · 2016Article
- First-Step Mutations during Adaptation Restore the Expression of Hundreds of Genes.Molecular biology and evolution · 2016Article
- Costs of antibiotic resistance - separating trait effects and selective effects.Evolutionary applications · 2015Review
- The impact of drug resistance on Mycobacterium tuberculosis physiology: what can we learn from rifampicin?Emerging microbes & infections · 2014Review
- Revealing the genetic basis of natural bacterial phenotypic divergence.Journal of bacteriology · 2014Article
- Evolution of Escherichia coli rifampicin resistance in an antibiotic-free environment during thermal stress.BMC evolutionary biology · 2013Article
- Fitness landscape transformation through a single amino acid change in the rho terminator.PLoS genetics · 2012Article
- New insights into bacterial adaptation through in vivo and in silico experimental evolution.Nature reviews. Microbiology · 2012Review
- Unravelling evolutionary strategies of yeast for improving galactose utilization through integrated systems level analysis.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Microbial laboratory evolution in the era of genome-scale science.Molecular systems biology · 2011Review
- Functional and metabolic effects of adaptive glycerol kinase (GLPK) mutants in Escherichia coli.The Journal of biological chemistry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We measured the relative fitness among a set of experimentally evolved Escherichia coli strains differing by a small number of adaptive mutations by directly measuring allelic frequencies in head-to-head competitions using a mass spectrometry-based method. We compared the relative effects of mutations to the same or similar genes acquired in multiple strains when expressed in allele replacement strains. We found that the strongest determinant of fitness among the evolved strains was the impact of beneficial mutations to the RNA polymerase beta and beta' subunit genes. We also identified several examples of epistatic interactions between rpoB/C and glpK mutations and identified two other mutations that are beneficial only in the presence of previously acquired mutations but that have little or no adaptive benefit to the wild-type strain. Allele frequency estimation is shown to be a highly sensitive method for measuring selection rates during competitions between strains differing by as little as a single-nucleotide polymorphism and may be of great use for investigating epistatic interactions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.