ArticleJournal of bacteriology2008
mgtA Expression is induced by rob overexpression and mediates a Salmonella enterica resistance phenotype.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- An updated overview on the bacterial PhoP/PhoQ two-component signal transduction system.Frontiers in cellular and infection microbiology · 2025Review
- Widespread fungal-bacterial competition for magnesium lowers bacterial susceptibility to polymyxin antibiotics.PLoS biology · 2024Article
- Drug resistance and physiological roles of RND multidrug efflux pumps inMicrobiology (Reading, England) · 2023Article
- Loss of CorA, the primary magnesium transporter of Salmonella, is alleviated by MgtA and PhoP-dependent compensatory mechanisms.PloS one · 2023Article
- Analyzing Thermal Stability of Cell Membrane of Salmonella Using Time-Multiplexed Impedance Sensing.Biophysical journal · 2018Article
- AraC/XylS family stress response regulators Rob, SoxS, PliA, and OpiA in the fire blight pathogen Erwinia amylovora.Journal of bacteriology · 2014Article
- Bacterial Mg2+ homeostasis, transport, and virulence.Annual review of genetics · 2013Review
- Response of P. aeruginosa E(1) gene expression to cadmium stress.Current microbiology · 2012Article
- Tandem attenuators control expression of the Salmonella mgtCBR virulence operon.Molecular microbiology · 2012Article
- The promoter architectural landscape of the Salmonella PhoP regulon.Molecular microbiology · 2012Article
- Mg2+ facilitates leader peptide translation to induce riboswitch-mediated transcription termination.The EMBO journal · 2011Article
- Serratia marcescens is able to survive and proliferate in autophagic-like vacuoles inside non-phagocytic cells.PloS one · 2011Article
- A bacterial mRNA leader that employs different mechanisms to sense disparate intracellular signals.Cell · 2010Article
- Promoter and riboswitch control of the Mg2+ transporter MgtA from Salmonella enterica.Journal of bacteriology · 2010Article
- Increased expression of Mg(2+) transport proteins enhances the survival of Salmonella enterica at high temperature.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rob is a member of the Sox/Mar subfamily of AraC/XylS-type transcriptional regulators implicated in bacterial multidrug, heavy metal, superoxide, and organic solvent resistance phenotypes. We demonstrate that, in Salmonella enterica, Rob overexpression upregulates the transcription of mgtA, which codes for the MgtA Mg2+ transporter. mgtA was previously characterized as a member of the Mg2+-modulated PhoPQ regulon. Here we demonstrate that Rob (but not its paralog protein SoxS or MarA) is able to induce mgtA transcription in a PhoP-independent fashion by binding to a conserved Mar/Sox/Rob motif localized downstream of the PhoP-box and overlapping the PhoP-dependent transcriptional start site. We found that Rob-induced mgtA expression confers low-level cyclohexane resistance on Salmonella. Because mgtA intactness is required for Rob-induced cyclohexane resistance, provided the AcrAB multidrug efflux pump can be expressed, we postulate that MgtA is involved in the AcrAB-mediated cyclohexane detoxification mechanism promoted by Rob in Salmonella.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.