ArticleScience (New York, N.Y.)2008
Design logic of a cannabinoid receptor signaling network that triggers neurite outgrowth.
Article in Science (New York, N.Y.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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The trial behind it
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Who cites it
83 citing papers in PubMed.
- Prenatal Downregulation of CBThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
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- Cellular forgetting, desensitisation, stress and ageing in signalling networks. When do cells refuse to learn more?Cellular and molecular life sciences : CMLS · 2024Review
- A spatially specified systems pharmacology therapy for axonal recovery after injury.Frontiers in pharmacology · 2023Article
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- Brain is modulated by neuronal plasticity during postnatal development.The journal of physiological sciences : JPS · 2021Review
- Extracellular histones, a new class of inhibitory molecules of CNS axonal regeneration.Brain communications · 2021Article
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- Life-long epigenetic programming of cortical architecture by maternal 'Western' diet during pregnancy.Molecular psychiatry · 2020Article
- Prenatal drug exposure and neurodevelopmental programming of glucocorticoid signalling.Journal of neuroendocrinology · 2020Review
- Indole compounds withMedChemComm · 2019Article
- Transcriptomic Analysis Identifies RNA Binding Proteins as Putative Regulators of Myelopoiesis and Leukemia.Frontiers in oncology · 2019Article
- A BRCA1-Dependent DNA Damage Response in the Regenerating Adult Peripheral Nerve Milieu.Molecular neurobiology · 2018Article
- Brca1 Is Upregulated by 5-Aza-CdR and Promotes DNA Repair and Cell Survival, and Inhibits Neurite Outgrowth in Rat Retinal Neurons.International journal of molecular sciences · 2018Article
- Biophysics of Biochemical Signaling in Dendritic Spines: Implications in Synaptic Plasticity.Biophysical journal · 2017Review
- Perspectives on the Role of Endocannabinoids in Autism Spectrum Disorders.OBM neurobiology · 2017Article
- TNF-insulin crosstalk at the transcription factor GATA6 is revealed by a model that links signaling and transcriptomic data tensors.Science signaling · 2016Article
- Identification of GPR83 as the receptor for the neuroendocrine peptide PEN.Science signaling · 2016Article
- Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Cannabinoid receptor 1 (CB1R) regulates neuronal differentiation. To understand the logic underlying decision-making in the signaling network controlling CB1R-induced neurite outgrowth, we profiled the activation of several hundred transcription factors after cell stimulation. We assembled an in silico signaling network by connecting CB1R to 23 activated transcription factors. Statistical analyses of this network predicted a role for the breast cancer 1 protein BRCA1 in neuronal differentiation and a new pathway from CB1R through phosphoinositol 3-kinase to the transcription factor paired box 6 (PAX6). Both predictions were experimentally confirmed. Results of transcription factor activation experiments that used pharmacological inhibitors of kinases revealed a network organization of partial OR gates regulating kinases stacked above AND gates that control transcription factors, which together allow for distributed decision-making in CB1R-induced neurite outgrowth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.