Evidence map›Paper›PMID 18486616›Full record

ArticleGastroenterology2008

Unraveling the role of PD-1/PD-L interactions in persistent hepatotropic infections: potential for therapeutic application?

Henry Radziewicz, Holly L Hanson, Rafi Ahmed, Arash Grakoui

Abstract readEditorialComment
PubMed Publisher
In one paragraph

Article in Gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Regulatory T cells use programmed death 1 ligands to directly suppress autoreactive B cells in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2012
    Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Henry Radziewicz
Holly L Hanson
Rafi Ahmed
Arash Grakoui

Funding

YNPRC NHP CLINICAL MEDICINE RESIDENCY PROGRAM - SUPPLEMENTP51RR000165 · NCRR · EMORY UNIVERSITY · PI ALTMAN, JOHN DAVID · 1985 to 2011
$114.0M
Transgenic/KnockoutP01AI056299 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI SHARPE, ARLENE H. · 2003 to 2023
$42.5M
Mechanisms of hepatitis C virus persistenceR01AI070101 · NIAID · EMORY UNIVERSITY · PI GRAKOUI, ARASH · 2006 to 2016
$3.9M
Mechanisms of T cell dysfunction in Hepatitis C virus persistenceK08AI072191 · NIAID · EMORY UNIVERSITY · PI RADZIEWICZ, HENRY THOMAS · 2007 to 2010
$513k
Mechanisms of hepatitis C virus persistenceR56AI070101 · NIAID · EMORY UNIVERSITY · PI GRAKOUI, ARASH · 2011 to 2011
$437k
NCRR NIH HHS RR-00165NIAID NIH HHS AI070101NIAID NIH HHS AI56299NIAID NIH HHS K08 AI072191
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antigens, CDAntiviral AgentsApoptosis Regulatory ProteinsB7-H1 AntigenCD8-Positive T-LymphocytesCell CompartmentationHepatitis B, ChronicHepatitis C, ChronicHumansLiverLymphocyte ActivationPhenotypeProgrammed Cell Death 1 ReceptorSignal TransductionAntigens, CDAntiviral AgentsApoptosis Regulatory ProteinsB7-H1 AntigenCD274 protein, humanPDCD1 protein, humanProgrammed Cell Death 1 Receptor

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.