Evidence map›Paper›PMID 18485491›Full record

ArticleJournal of neuroimmunology2008

Characterization of ganglionic acetylcholine receptor autoantibodies.

Steven Vernino, Jon Lindstrom, Steve Hopkins, Zhengbei Wang, Phillip A Low, Muscle Study Group

Open access · greenAbstract readComparative Study
In one paragraph

Article in Journal of neuroimmunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 82 citations in OpenAlex.

  1. Article
  2. Autoimmune autonomic ganglionopathy and myasthenia gravis: a case report and review of the literature.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Autonomic nervous system involvement in chronic inflammatory demyelinating polyradiculoneuropathy: a literature review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Autoimmune autonomic neuropathies and ganglionopathies: epidemiology, pathophysiology, and therapeutic advances.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Steven VerninoDepartment of Neurology, UT Southwestern Medical Center, Dallas Texas 75390-9036, United States. steven.vernino@utsouthwestern.edu
Jon Lindstrom
Steve Hopkins
Zhengbei Wang
Phillip A Low
Muscle Study Group
Mayo Clinic · USSouthwestern Medical CenterSouthwestern Medical Center · USThe University of Texas Southwestern Medical Center · USUniversity of Pennsylvania · US

Funding

SYMPATHETIC REGULATION OF VENOUS FUNCTION IN ORTHOSTATIC INTOLERANCE AND AGINGP50NS032352 · NINDS · MAYO CLINIC ROCHESTER · PI LOW, PHILLIP A · 1996 to 2009
$11.4M
STUDIES USING PURIFIED ACETYLCHOLINE RECEPTORSR01NS011323 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI LINDSTROM, JON MARTIN · 1985 to 2012
$5.0M
EAMG: MIR structure and specific immunosuppressive therapyR01NS052463 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI LINDSTROM, JON MARTIN · 2006 to 2009
$1.7M
Experimental Dysautonomia: Pathogenesis and TreatmentR01NS048077 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI VERNINO, STEVEN A · 2004 to 2006
$630k
NINDS NIH HHS NS011323NINDS NIH HHS NS052463NINDS NIH HHS P50 NS032352NINDS NIH HHS P50NS32352NINDS NIH HHS R01 NS011323NINDS NIH HHS R01 NS048077NINDS NIH HHS R01 NS052463
6 · The paper itself

Abstract

In myasthenia gravis (MG), autoantibodies bind to the alpha1 subunit and other subunits of the muscle nicotinic acetylcholine receptor (AChR). Autoimmune autonomic ganglionopathy (AAG) is an antibody-mediated neurological disorder caused by antibodies against neuronal AChRs in autonomic ganglia. Subunits of muscle and neuronal AChR are homologous. We examined the specificity of AChR antibodies in patients with MG and AAG. Ganglionic AChR autoantibodies found in AAG patients are specific for AChRs containing the alpha3 subunit. Muscle and ganglionic AChR antibody specificities are distinct. Antibody crossreactivity between AChRs with different alpha subunits is uncommon but can occur.

Indexed as

alpha7 Nicotinic Acetylcholine ReceptorAnimalsAutoantibodiesAutoimmune Diseases of the Nervous SystemAutonomic Nervous System DiseasesCell LineCell Line, TumorGanglia, AutonomicHumansMiceMice, NudeMuscle, SkeletalRabbitsReceptors, MuscarinicReceptors, Nicotinicalpha7 Nicotinic Acetylcholine ReceptorAutoantibodiesChrna7 protein, humanChrna7 protein, mousenicotinic receptor alpha3beta2nicotinic receptor alpha3beta4nicotinic receptor alpha4beta2Receptors, MuscarinicReceptors, Nicotinic

Identifiers

PMID18485491
PMCPMC2536520
OpenAlexW2057982167

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.