ArticleAmerican journal of human genetics2008
A multilocus model of the genetic architecture of autoimmune thyroid disorder, with clinical implications.
Article in American journal of human genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Cytotoxic T-lymphocyte associated antigen 4 polymorphism and Hashimoto's thyroiditis susceptibility: a meta-analysis.Endocrine · 2014Pooled it
- Cytotoxic T-lymphocyte-associated protein 4 +49A/G polymorphism in Down syndrome children with Hashimoto's thyroiditis.Biomolecules & biomedicine · 2023Article
- Genetic Susceptibility to Joint Occurrence of Polycystic Ovary Syndrome and Hashimoto's Thyroiditis: How Far Is Our Understanding?Frontiers in immunology · 2021Review
- Linkage Analysis of Genomic Regions Contributing to the Expression of Type 1 Diabetes Microvascular Complications and Interaction with HLA.Journal of diabetes research · 2015Article
- Revisiting schizophrenia linkage data in the NIMH Repository: reanalysis of regularized data across multiple studies.The American journal of psychiatry · 2014Article
- Fine mapping of loci linked to autoimmune thyroid disease identifies novel susceptibility genes.The Journal of clinical endocrinology and metabolism · 2013Article
- How should we be searching for genes for common epilepsy? A critique and a prescription.Epilepsia · 2012Review
- CTLA-4 gene polymorphisms and their influence on predisposition to autoimmune thyroid diseases (Graves' disease and Hashimoto's thyroiditis).Archives of medical science : AMS · 2012Article
- Evaluation of a bayesian model integration-based method for censored data.Human heredity · 2012Article
- No major genes in autoimmune thyroid diseases: complex segregation and epidemiological studies in a large Tunisian pedigree.Journal of genetics · 2011Article
- Novel method for combined linkage and genome-wide association analysis finds evidence of distinct genetic architecture for two subtypes of autism.Journal of neurodevelopmental disorders · 2011Article
- IFN-α mediates the development of autoimmunity both by direct tissue toxicity and through immune cell recruitment mechanisms.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- KELVIN: a software package for rigorous measurement of statistical evidence in human genetics.Human heredity · 2011Article
- Genetic susceptibility to autoimmune thyroid disease: past, present, and future.Thyroid : official journal of the American Thyroid Association · 2010Review
- Increasing genotype-phenotype model determinism: application to bivariate reading/language traits and epistatic interactions in language-impaired families.Human heredity · 2010Article
- Fast and accurate calculation of a computationally intensive statistic for mapping disease genes.Journal of computational biology : a journal of computational molecular cell biology · 2009Article
- Autoimmune thyroiditis and diabetes: dissecting the joint genetic susceptibility in a large cohort of multiplex families.The Journal of clinical endocrinology and metabolism · 2009Article
- Evidence that shed thyrotropin receptor A subunits drive affinity maturation of autoantibodies causing Graves' disease.The Journal of clinical endocrinology and metabolism · 2009Article
- 'Linkage analysis of thyroid antibody production: evidence for shared susceptibility to clinical autoimmune thyroid disease.The Journal of clinical endocrinology and metabolism · 2008Article
- The etiology of autoimmune thyroid disease: a story of genes and environment.Journal of autoimmunityArticle
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
We report here a preliminary model of the genetic architecture of Autoimmune Thyroid Disorder (AITD). Using a flexible class of mathematical modeling techniques, applied to an established set of data and supplemented with information both from candidate-gene and genome-wide-association studies and from basic bioinformatics, we find strong statistical support for a model in which AITD is the result of "hits" along three distinct genetic pathways: affected individuals have (1) a genetic susceptibility to clinical AITD, along with (2) a separate predisposition to develop the autoantibodies characteristic of AITD, and they also have (3) a predisposition to develop high levels of autoantibodies once they occur. Genes underlying each of these factors then appear to interact with one another to cause clinical AITD. We also find that a genetic variant in CTLA4 that increases risk for AITD in some people might actually protect against AITD in others, depending on which additional risk variants an individual carries. Our data show that the use of statistical methods for the incorporation of information from multiple sources, combined with careful modeling of distinct intermediate phenotypes, can provide insights into the genetic architecture of complex diseases. This model has several clinical implications, which we believe will prove relevant to other complex diseases as well.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.