Evidence map›Paper›PMID 18483850›Full record

ArticleAIDS and behavior2009

Implementation of the Medicare Part D prescription drug benefit is associated with antiretroviral therapy interruptions.

Moupali Das-Douglas, Elise D Riley, Kathleen Ragland, David Guzman, Richard Clark, Margot B Kushel, David R Bangsberg

Abstract read
In one paragraph

Article in AIDS and behavior, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  17. Average adherence to boosted protease inhibitor therapy, rather than the pattern of missed doses, as a predictor of HIV RNA replication.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2010
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Moupali Das-DouglasDepartment of Medicine, Division of Infectious Diseases, University of California, San Francisco, CA, 94143, USA. moupali.das-douglas@ucsf.edu.
Elise D Riley
Kathleen Ragland
David Guzman
Richard Clark
Margot B Kushel
David R Bangsberg

Funding

TB PREVENTION AND HIV IN THE HOMELESS--AN INTERVENTIONR01MH054907 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BANGSBERG, DAVID ROY · 1995 to 2014
$20.7M
TRAINEESHIPS IN AIDS PREVENTION STUDIEST32MH019105 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Carol Suzanne Camlin, Glenn-Milo Santos · 1989 to 2026
$15.3M
Mentoring Patient Oriented Adherence Research in UgandaK24MH087227 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BANGSBERG, DAVID ROY · 2009 to 2013
$776k
HIV Outcomes Research and Training in UgandaK24AA015287 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BANGSBERG, DAVID ROY · 2004 to 2008
$680k
NIAAA NIH HHS AA015287NIMH NIH HHS K24 MH087227NIMH NIH HHS R01 MH054907NIMH NIH HHS T32 MH019105NIMH NIH HHS T32MH19105PHS HHS 54907
6 · The paper itself

Abstract

Antiretroviral (ARV) treatment interruptions are associated with virologic rebound, drug resistance, and increased morbidity and mortality. The Medicare Part D prescription drug benefit, implemented on January 1st, 2006, increased consumer cost-sharing. Consumer cost-sharing is associated with decreased access to medications and adverse clinical outcomes. We assessed the association of Part D implementation with treatment interruptions by studying 125 HIV-infected homeless and marginally housed individuals with drug coverage receiving ARV therapy. Thirty-five percent of respondents reported Medicare coverage and 11% reported ARV interruptions. The odds of ARV interruptions were six times higher among those with Part D coverage and remained significant after adjustment. The majority of Part D-covered respondents reporting ARV interruptions cited increased cost as their primary barrier. Directed interventions to monitor the long-term effects of increased cost burden on interruptions and clinical outcomes and to reduce cost burden are necessary to avoid preventable increases in morbidity and mortality.

Indexed as

Drug MonitoringMedicare Part DAdultAnti-HIV AgentsCohort StudiesCost SharingFemaleHealth Knowledge, Attitudes, PracticeHIV InfectionsHumansMaleMiddle AgedSocioeconomic FactorsUnited StatesAnti-HIV Agents

Identifiers

PMID18483850
PMCPMC3591735

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.